Relationship of tgf-β1 and mthfr gene polymorphism with the development of varicose disease and its thrombotic complications

А.А. Яриев, С.С. Худойбердиев, Kodirjon BOBOEV, А. Мохаммад Дин, Ш.М. Муминов, Б.И. Шукуров

Shoshilinch tibbiyot axborotnomasi · 2023-yil

Annotatsiya

Aim. Identification the association of TGF-β1 and MTHFR genes with the development of lower extremityvaricose disease and its thrombotic complications.Material and methods. 161 patients with varicose disease (main group) were examined: 111 patientswithout thrombotic complications, 50 with phlebothrombosis. The control group included 155 conditionally healthy individuals. We studied the frequency of carriage of the G/G, G/C, C/C genotypes of thers1800471 polymorphism in the TGF-β1 gene and the C/C, C/T, T/T genotypes of the rs1801133 polymorphism in the MTHFR gene.Results. Among patients with venous thrombosis, the frequency of carriage of the heterozygous G/C genotype TGF-β1 gene and the mutant homozygous T/T genotype MTHFR gene was almost 4 times higherthan in control group (χ2>3,84; p<0,05; OR=3,9; 95% CI:1,64–8,98 and χ2>3,84; p<0,05; OR=3,1; 95%CI:1,11–8,49, respectively).Conclusions. The presence of the heterozygous G/C genotype of the TGF-β1 gene and the homozygousT/T genotype of the MTHFR gene has diagnostic and prognostic significance and greatly increases the riskof developing varicose disease and phlebothrombosis.

Maqola ma’lumotlari
MualliflarА.А. Яриев, С.С. Худойбердиев, Kodirjon BOBOEV, А. Мохаммад Дин, Ш.М. Муминов, Б.И. Шукуров
JurnalShoshilinch tibbiyot axborotnomasi
NashriyotЎзбекистон шошилинч тиббий ёрдам врачлари, ассоциацияси
ISSN2010-9881
Nashr sanasi2023-01-01
Jild15
Son5
TilIngliz
Ilmiy sohaTibbiyot
DOI10.54185/tbem/vol15_iss5/a5
Indeksga qo‘shilgan2026-09-02

DOI: 10.54185/tbem/vol15_iss5/a5 · Maqolaning asl sahifasi

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APAА.А. Яриев, С.С. Худойбердиев, Kodirjon BOBOEV, А. Мохаммад Дин, Ш.М. Муминов, & Б.И. Шукуров (2023). Relationship of tgf-β1 and mthfr gene polymorphism with the development of varicose disease and its thrombotic complications. Shoshilinch tibbiyot axborotnomasi, 15(5). https://doi.org/10.54185/tbem/vol15_iss5/a5
GOST (OAK)А.А. Яриев va b. Relationship of tgf-β1 and mthfr gene polymorphism with the development of varicose disease and its thrombotic complications // Shoshilinch tibbiyot axborotnomasi. – 2023. – T. 15, № 5. – DOI: 10.54185/tbem/vol15_iss5/a5.
MLAА.А. Яриев, С.С. Худойбердиев, Kodirjon BOBOEV, А. Мохаммад Дин, Ш.М. Муминов, and Б.И. Шукуров. “Relationship of tgf-β1 and mthfr gene polymorphism with the development of varicose disease and its thrombotic complications.” Shoshilinch tibbiyot axborotnomasi, 15(5), 2023. https://doi.org/10.54185/tbem/vol15_iss5/a5
ChicagoА.А. Яриев, С.С. Худойбердиев, Kodirjon BOBOEV, А. Мохаммад Дин, Ш.М. Муминов, and Б.И. Шукуров. “Relationship of tgf-β1 and mthfr gene polymorphism with the development of varicose disease and its thrombotic complications.” Shoshilinch tibbiyot axborotnomasi, 15(5) (2023). https://doi.org/10.54185/tbem/vol15_iss5/a5
HarvardА.А. Яриев, С.С. Худойбердиев, Kodirjon BOBOEV, А. Мохаммад Дин, Ш.М. Муминов, and Б.И. Шукуров (2023) ‘Relationship of tgf-β1 and mthfr gene polymorphism with the development of varicose disease and its thrombotic complications’, Shoshilinch tibbiyot axborotnomasi, 15(5). https://doi.org/10.54185/tbem/vol15_iss5/a5
BibTeX
@article{article2023,
  title = {Relationship of tgf-β1 and mthfr gene polymorphism with the development of varicose disease and its thrombotic complications},
  author = {А.А. Яриев and С.С. Худойбердиев and Kodirjon BOBOEV and А. Мохаммад Дин and Ш.М. Муминов and Б.И. Шукуров},
  journal = {Shoshilinch tibbiyot axborotnomasi},
  year = {2023},
  volume = {15},
  number = {5},
  doi = {10.54185/tbem/vol15_iss5/a5},
  url = {https://doi.org/10.54185/tbem/vol15_iss5/a5}
}

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