Decline of Renal Function and Progression of Left Ventricular Hypertrophy Are Independently Determined in Chronic Kidney Disease Stages 3-5

Hiromichi Suzuki, Tsutomu Inoue, Mami Dogi, Tomohiro Kikuta, Tsuneo Takenaka, Hirokazu Okada

PULSE · 2014-yil

Annotatsiya

UNLABELLED: Invasive and noninvasive methods for evaluating the effects of hemodynamics on progression of left ventricular hypertrophy (LVH) in patients with chronic kidney disease (CKD) have been proposed. Central aortic pressure (CAP) has been reported to be the best among selected measures of hemodynamics for predicting LVH. However, there are few studies examining the relation between longitudinal changes in CAP and renal dysfunction in patients with CKD. METHODS: Sixty-seven patients with CKD stages 3-5 (female/male ratio: 26/41, age: 61.5 ± 13.1 years) were followed for 5 years. Before and at the end of the 5-year period, CAP was recorded by an automated tonometric system (HEM-9000 AI; Omron Healthcare, Kyoto, Japan). Second systolic aortic blood pressure (SBP2) was employed as an index of CAP. RESULTS: Throughout the study, systolic blood pressure (SBP) was well controlled. Renal function followed by estimated glomerular filtration rate (eGFR) gradually worsened as a whole. Ten patients had renal replacement therapy, 3 patients developed cardiovascular diseases and 2 patients were found to have a neoplasm during the 5-year observation period. SBP2 increased from 120 ± 19 to 125 ± 33 mm Hg and eGFR decreased from 38.2 ± 18.2 to 29.5 ± 16.3 ml/min/1.73 m(2); however, these differences did not achieve significance. The left ventricular mass (LVM) index significantly increased from 115.5 ± 10.5 to 131.2 ± 11.7 g/m(2) (p < 0.05). Although the changes in SBP2 and eGFR looked like a mirror image, there was no significant correlation between the two factors. Moreover, multivariate regression analysis did not reveal a close correlation between SBP2 and CKD progression. In contrast to the decline of renal function, the baseline value of SBP2 predicted an increase in the LVM index. CONCLUSION: Worsening of renal dysfunction is not solely dependent on hemodynamics. Other factors might be involved in a complex manner.

Maqola ma’lumotlari
MualliflarHiromichi Suzuki, Tsutomu Inoue, Mami Dogi, Tomohiro Kikuta, Tsuneo Takenaka, Hirokazu Okada
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2014-01-01
Jild2
Son1-4
Betlar29-37
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000368678
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000368678 · Maqolaning asl sahifasi

Ilmiy soha

Psixologiya

Iqtibos keltirish

APAHiromichi Suzuki, Tsutomu Inoue, Mami Dogi, Tomohiro Kikuta, Tsuneo Takenaka, & Hirokazu Okada (2014). Decline of Renal Function and Progression of Left Ventricular Hypertrophy Are Independently Determined in Chronic Kidney Disease Stages 3-5. PULSE, 2(1-4), 29-37. https://doi.org/10.1159/000368678
GOST (OAK)Hiromichi Suzuki va b. Decline of Renal Function and Progression of Left Ventricular Hypertrophy Are Independently Determined in Chronic Kidney Disease Stages 3-5 // PULSE. – 2014. – T. 2, № 1-4. – P. 29-37. – DOI: 10.1159/000368678.
MLAHiromichi Suzuki, Tsutomu Inoue, Mami Dogi, Tomohiro Kikuta, Tsuneo Takenaka, and Hirokazu Okada. “Decline of Renal Function and Progression of Left Ventricular Hypertrophy Are Independently Determined in Chronic Kidney Disease Stages 3-5.” PULSE, 2(1-4), 29-37, 2014. https://doi.org/10.1159/000368678
ChicagoHiromichi Suzuki, Tsutomu Inoue, Mami Dogi, Tomohiro Kikuta, Tsuneo Takenaka, and Hirokazu Okada. “Decline of Renal Function and Progression of Left Ventricular Hypertrophy Are Independently Determined in Chronic Kidney Disease Stages 3-5.” PULSE, 2(1-4), 29-37 (2014). https://doi.org/10.1159/000368678
HarvardHiromichi Suzuki, Tsutomu Inoue, Mami Dogi, Tomohiro Kikuta, Tsuneo Takenaka, and Hirokazu Okada (2014) ‘Decline of Renal Function and Progression of Left Ventricular Hypertrophy Are Independently Determined in Chronic Kidney Disease Stages 3-5’, PULSE, 2(1-4), 29-37. https://doi.org/10.1159/000368678
BibTeX
@article{hiromichisuzuki2014,
  title = {Decline of Renal Function and Progression of Left Ventricular Hypertrophy Are Independently Determined in Chronic Kidney Disease Stages 3-5},
  author = {Hiromichi Suzuki and Tsutomu Inoue and Mami Dogi and Tomohiro Kikuta and Tsuneo Takenaka and Hirokazu Okada},
  journal = {PULSE},
  year = {2014},
  volume = {2},
  number = {1-4},
  pages = {29-37},
  doi = {10.1159/000368678},
  url = {https://doi.org/10.1159/000368678}
}

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