Association between Beta-Fibrinogen C148T Gene Polymorphism and Risk of Ischemic Stroke in a North Indian Population: A Case-Control Study

Amit Kumar, Shubham Misra, Pradeep Kumar, Ram Sagar, Kameshwar Prasad

PULSE · 2016-yil

Annotatsiya

BACKGROUND AND PURPOSE: Stroke is a multifactorial disease influenced by both genetic and environmental factors. The aim of this case-control study was to determine the association between β-fibrinogen C148T (rs1800787) gene polymorphism and susceptibility to ischemic stroke (IS) in a North Indian population. METHODS: In the present case-control study, genotyping was performed using the PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) method on 250 IS patients and 250 age- and sex-matched controls. Frequency distributions of genotypes and alleles were compared between the cases and controls by conditional logistic regression. RESULTS: Hypertension, diabetes, dyslipidemia, low socioeconomic status, and family history of stroke were found to be independent risk factors for IS. The mean age of the cases and controls was 52.83 ± 12.59 and 50.97 ± 12.70 years, respectively. Multivariate logistic regression analysis showed an independent association between β-fibrinogen C148T (rs1800787) polymorphism and risk of IS in dominant (OR = 2.19; 95% CI 1.23-3.90; p = 0.007) and allelic (OR = 1.66; 95% CI 1.19-2.33; p = 0.002) models. Based on the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification, an independent association of small vessel disease with risk of IS was observed in the dominant (OR = 2.09; 95% CI 1.10-3.96; p = 0.02) and allelic (OR = 1.75; 95% CI 1.12-2.75; p = 0.01) models, and a significant association of cardioembolic stroke with risk of IS was seen in the allelic model (OR = 2.11; 95% CI 1.07-4.17; p = 0.02). All the genotype frequencies observed were in accordance with Hardy-Weinberg equilibrium in both cases and controls. CONCLUSION: The findings of the present study suggest that polymorphism in the C148T position of the β-fibrinogen gene might be a risk factor for IS mainly for the small vessel disease stroke subtype in a North Indian population. Further, large prospective studies are required to confirm these findings.

Maqola ma’lumotlari
MualliflarAmit Kumar, Shubham Misra, Pradeep Kumar, Ram Sagar, Kameshwar Prasad
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2016-01-01
Jild4
Son4
Betlar165-171
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000449361
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000449361 · Maqolaning asl sahifasi · PDF

Ilmiy soha

Psixologiya

Iqtibos keltirish

APAAmit Kumar, Shubham Misra, Pradeep Kumar, Ram Sagar, & Kameshwar Prasad (2016). Association between Beta-Fibrinogen C148T Gene Polymorphism and Risk of Ischemic Stroke in a North Indian Population: A Case-Control Study. PULSE, 4(4), 165-171. https://doi.org/10.1159/000449361
GOST (OAK)Amit Kumar va b. Association between Beta-Fibrinogen C148T Gene Polymorphism and Risk of Ischemic Stroke in a North Indian Population: A Case-Control Study // PULSE. – 2016. – T. 4, № 4. – P. 165-171. – DOI: 10.1159/000449361.
MLAAmit Kumar, Shubham Misra, Pradeep Kumar, Ram Sagar, and Kameshwar Prasad. “Association between Beta-Fibrinogen C148T Gene Polymorphism and Risk of Ischemic Stroke in a North Indian Population: A Case-Control Study.” PULSE, 4(4), 165-171, 2016. https://doi.org/10.1159/000449361
ChicagoAmit Kumar, Shubham Misra, Pradeep Kumar, Ram Sagar, and Kameshwar Prasad. “Association between Beta-Fibrinogen C148T Gene Polymorphism and Risk of Ischemic Stroke in a North Indian Population: A Case-Control Study.” PULSE, 4(4), 165-171 (2016). https://doi.org/10.1159/000449361
HarvardAmit Kumar, Shubham Misra, Pradeep Kumar, Ram Sagar, and Kameshwar Prasad (2016) ‘Association between Beta-Fibrinogen C148T Gene Polymorphism and Risk of Ischemic Stroke in a North Indian Population: A Case-Control Study’, PULSE, 4(4), 165-171. https://doi.org/10.1159/000449361
BibTeX
@article{amitkumar2016,
  title = {Association between Beta-Fibrinogen C148T Gene Polymorphism and Risk of Ischemic Stroke in a North Indian Population: A Case-Control Study},
  author = {Amit Kumar and Shubham Misra and Pradeep Kumar and Ram Sagar and Kameshwar Prasad},
  journal = {PULSE},
  year = {2016},
  volume = {4},
  number = {4},
  pages = {165-171},
  doi = {10.1159/000449361},
  url = {https://doi.org/10.1159/000449361}
}

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