Circulating Serum Magnesium and the Risk of Venous Thromboembolism in Men: A Long-Term Prospective Cohort Study

Setor K. Kunutsor, Jari A. Laukkanen

PULSE · 2020-yil

Annotatsiya

BACKGROUND AND OBJECTIVE: Serum magnesium, an essential trace element involved in processes that regulate cardiovascular function, has been linked to the risk of atherosclerotic cardiovascular disease. However, the potential association between serum magnesium and venous thromboembolism (VTE) has not been previously investigated. We aimed to assess the prospective association of serum magnesium with the risk of VTE. METHODS: Serum magnesium was measured using atomic absorption spectrometry in 2,361 men aged 42-61 years with no history of VTE at baseline in the Kuopio Ischemic Heart Disease prospective cohort. Cox regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for VTE. RESULTS: A total of 159 incident VTE events were recorded during a median follow-up of 27.1 years. The risk of VTE per 1 SD increase in serum magnesium in the age-adjusted analysis was (HR 1.30; 95% CI 0.46-3.69). The association remained consistent in analyses adjusted for systolic blood pressure, body mass index, total cholesterol, triglycerides, smoking status, a history of type 2 diabetes, a history of coronary heart disease, medication for dyslipidemia, alcohol consumption, physical activity, socioeconomic status, serum active calcium, high-sensitivity C-reactive protein, and a history of cancer (HR 1.38; 95% CI 0.48-3.96). Comparing the extreme tertiles of serum magnesium, the corresponding adjusted HRs were 1.17 (95% CI 0.81-1.70) and 1.17 (95% CI 0.81-1.70), respectively. CONCLUSION: In a middle-aged Caucasian male population, serum-circulating magnesium was not associated with a future risk of VTE. Further studies in women, other age groups, and other populations are required to generalize these findings.

Maqola ma’lumotlari
MualliflarSetor K. Kunutsor, Jari A. Laukkanen
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2020-01-01
Jild8
Son3-4
Betlar108-113
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000515409
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000515409 · Maqolaning asl sahifasi · PDF

Ilmiy soha

Psixologiya

Iqtibos keltirish

APASetor K. Kunutsor, & Jari A. Laukkanen (2020). Circulating Serum Magnesium and the Risk of Venous Thromboembolism in Men: A Long-Term Prospective Cohort Study. PULSE, 8(3-4), 108-113. https://doi.org/10.1159/000515409
GOST (OAK)Setor K. Kunutsor, Jari A. Laukkanen Circulating Serum Magnesium and the Risk of Venous Thromboembolism in Men: A Long-Term Prospective Cohort Study // PULSE. – 2020. – T. 8, № 3-4. – P. 108-113. – DOI: 10.1159/000515409.
MLASetor K. Kunutsor, and Jari A. Laukkanen. “Circulating Serum Magnesium and the Risk of Venous Thromboembolism in Men: A Long-Term Prospective Cohort Study.” PULSE, 8(3-4), 108-113, 2020. https://doi.org/10.1159/000515409
ChicagoSetor K. Kunutsor, and Jari A. Laukkanen. “Circulating Serum Magnesium and the Risk of Venous Thromboembolism in Men: A Long-Term Prospective Cohort Study.” PULSE, 8(3-4), 108-113 (2020). https://doi.org/10.1159/000515409
HarvardSetor K. Kunutsor, and Jari A. Laukkanen (2020) ‘Circulating Serum Magnesium and the Risk of Venous Thromboembolism in Men: A Long-Term Prospective Cohort Study’, PULSE, 8(3-4), 108-113. https://doi.org/10.1159/000515409
BibTeX
@article{setorkkunutsor2020,
  title = {Circulating Serum Magnesium and the Risk of Venous Thromboembolism in Men: A Long-Term Prospective Cohort Study},
  author = {Setor K. Kunutsor and Jari A. Laukkanen},
  journal = {PULSE},
  year = {2020},
  volume = {8},
  number = {3-4},
  pages = {108-113},
  doi = {10.1159/000515409},
  url = {https://doi.org/10.1159/000515409}
}

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