Arterial Stiffness

Alberto Avolio

PULSE · 2013-yil

Annotatsiya

Stiffness of large arteries has been long recognized as a significant determinant of pulse pressure. However, it is only in recent decades, with the accumulation of longitudinal data from large and varied epidemiological studies of morbidity and mortality associated with cardiovascular disease, that it has emerged as an independent predictor of cardiovascular risk. This has generated substantial interest in investigations related to intrinsic causative and associated factors responsible for the alteration of mechanical properties of the arterial wall, with the aim to uncover specific pathways that could be interrogated to prevent or reverse arterial stiffening. Much has been written on the haemodynamic relevance of arterial stiffness in terms of the quantification of pulsatile relationships of blood pressure and flow in conduit arteries. Indeed, much of this early work regarded blood vessels as passive elastic conduits, with the endothelial layer considered as an inactive lining of the lumen and as an interface to flowing blood. However, recent advances in molecular biology and increased technological sophistication for the detection of low concentrations of biochemical compounds have elucidated the highly important regulatory role of the endothelial cell affecting vascular function. These techniques have enabled research into the interaction of the underlying passive mechanical properties of the arterial wall with the active cellular and molecular processes that regulate the local environment of the load-bearing components. This review addresses these emerging concepts.

Maqola ma’lumotlari
MualliflarAlberto Avolio
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2013-01-01
Jild1
Son1
Betlar14-28
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000348620
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000348620 · Maqolaning asl sahifasi · PDF

Ilmiy soha

Psixologiya

Iqtibos keltirish

APAAlberto Avolio (2013). Arterial Stiffness. PULSE, 1(1), 14-28. https://doi.org/10.1159/000348620
GOST (OAK)Alberto Avolio Arterial Stiffness // PULSE. – 2013. – T. 1, № 1. – P. 14-28. – DOI: 10.1159/000348620.
MLAAlberto Avolio. “Arterial Stiffness.” PULSE, 1(1), 14-28, 2013. https://doi.org/10.1159/000348620
ChicagoAlberto Avolio. “Arterial Stiffness.” PULSE, 1(1), 14-28 (2013). https://doi.org/10.1159/000348620
HarvardAlberto Avolio (2013) ‘Arterial Stiffness’, PULSE, 1(1), 14-28. https://doi.org/10.1159/000348620
BibTeX
@article{albertoavolio2013,
  title = {Arterial Stiffness},
  author = {Alberto Avolio},
  journal = {PULSE},
  year = {2013},
  volume = {1},
  number = {1},
  pages = {14-28},
  doi = {10.1159/000348620},
  url = {https://doi.org/10.1159/000348620}
}

Boshqa maqola uchun iqtibos tayyorlash

PULSE jurnalidan boshqa maqolalar

PULSE — barcha maqolalar · 2013-yil arxivi

Alberto Avolio — boshqa maqolalari

Psixologiya sohasidagi boshqa maqolalar

Psixologiya sohasidagi OAK jurnallari