The purpose of the study is to develop a new catalytic system for the synthesis of internal acetylene alcohols from the Sonogastric coupling reaction of terminal acetylene alcohols and benzolchloride. For the first time in this work, internal acetylene alcohols have been synthesized based on reactions of some terminal acetylene alcohols – 3,4-dimethylpentin-1-ol-3, 3,4,4-trimethylpentin-1-ol-3, 1-ethynylcyclohexanol-1, 2-ethynyladamantanol-2, 2-phenylbutin-3-ol-2, 2-(naphthyl-2)butyn-3-ol-2, 2-(furanyl-2)butyn-3-ol-2 and 2-(pyridinyl-4)butyn-3-ol-2 with chloridebenzene. In order to achieve high product productivity in the Sonogashira reaction, alternative conditions have been identified by studying the molar ratios, spatial structure, induction effects of substituents, solvent and catalyst nature, as well as temperature, reaction duration effects, and the reaction mechanism has been proposed on the basis of literature sources.
| Mualliflar | Guzal Otamukhamedova, Odiljon E. ZIYADULLAYEV, Abduvahob IKRAMOV, S.I Tirkasheva |
|---|---|
| Jurnal | Kimyo va kimyo texnologiyasi |
| Nashr sanasi | 2024-05-03 |
| Jild | 2024 |
| Son | 1 |
| Til | en |
| DOI | 10.70189/1992-9498.1549 |
DOI: 10.70189/1992-9498.1549 · Maqolaning asl sahifasi
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