Synthesis of the new heterocyclic derivatives of alkaloids

G.K. Mukusheva, Madina R. Aliyeva, Marzhan KAIYRBAYEVA, A.S. Mazhitov

Kimyo va kimyo texnologiyasi · 2024-yil

Annotatsiya

The aim of the study is the synthesis of heterocyclic derivatives of alkaloids. A convenient method has been developed for obtaining natural alkaloid derivatives of anabazine and cytisine by the acylation reaction of 1,2-azole-3-, pyridine-3-, pyridine-4- and adamantane-1-carbonyl chlorides. A number of N-acyl derivatives of anabazine and cytisine have been obtained for the discovery of new medicines based on natural products. Molecular docking of the studied compounds was carried out on a model of hemagglutinin (1 RAY 1930 Swine H1 Hemagglutinin) and neuraminidase (neuraminidase 3BEQ strain A/Brevig Mission/1/1918 H1N1) proteins. It was found that all the studied compounds are able to bind to hemagglutinin and neuraminidase. Computer modeling was carried out on the basis of the AutoDock Vina 1.1.2 program, as well as external tools such as AutoDock Tools. All synthesized compounds were tested for antiviral activity. Compounds with adamantane fragment showed the greatest antiviral effect. Adamantane derivatives of anabazine and cytisine showed pronounced antiviral properties, even surpassing the commercial drugs Tamiflu and Remantadine in activity. Derivatives of N-acyl anabazine and cytisine are promising for further study of their pharmacological properties.

Maqola ma’lumotlari
MualliflarG.K. Mukusheva, Madina R. Aliyeva, Marzhan KAIYRBAYEVA, A.S. Mazhitov
JurnalKimyo va kimyo texnologiyasi
NashriyotТошкент кимё-технология институти
ISSN1992-9498, 2181-1121
Nashr sanasi2024-03-28
Jild2023
Son2
TilIngliz
Ilmiy sohaKimyo
DOI10.70189/1992-9498.1591
Indeksga qo‘shilgan2026-09-02

DOI: 10.70189/1992-9498.1591 · Maqolaning asl sahifasi

Ilmiy soha

Kimyo

Iqtibos keltirish

APAG.K. Mukusheva, Madina R. Aliyeva, Marzhan KAIYRBAYEVA, & A.S. Mazhitov (2024). SYNTHESIS OF THE NEW HETEROCYCLIC DERIVATIVES OF ALKALOIDS. Kimyo va kimyo texnologiyasi, 2023(2). https://doi.org/10.70189/1992-9498.1591
GOST (OAK)G.K. Mukusheva va b. SYNTHESIS OF THE NEW HETEROCYCLIC DERIVATIVES OF ALKALOIDS // Kimyo va kimyo texnologiyasi. – 2024. – T. 2023, № 2. – DOI: 10.70189/1992-9498.1591.
MLAG.K. Mukusheva, Madina R. Aliyeva, Marzhan KAIYRBAYEVA, and A.S. Mazhitov. “SYNTHESIS OF THE NEW HETEROCYCLIC DERIVATIVES OF ALKALOIDS.” Kimyo va kimyo texnologiyasi, 2023(2), 2024. https://doi.org/10.70189/1992-9498.1591
ChicagoG.K. Mukusheva, Madina R. Aliyeva, Marzhan KAIYRBAYEVA, and A.S. Mazhitov. “SYNTHESIS OF THE NEW HETEROCYCLIC DERIVATIVES OF ALKALOIDS.” Kimyo va kimyo texnologiyasi, 2023(2) (2024). https://doi.org/10.70189/1992-9498.1591
HarvardG.K. Mukusheva, Madina R. Aliyeva, Marzhan KAIYRBAYEVA, and A.S. Mazhitov (2024) ‘SYNTHESIS OF THE NEW HETEROCYCLIC DERIVATIVES OF ALKALOIDS’, Kimyo va kimyo texnologiyasi, 2023(2). https://doi.org/10.70189/1992-9498.1591
BibTeX
@article{gkmukusheva2024,
  title = {SYNTHESIS OF THE NEW HETEROCYCLIC DERIVATIVES OF ALKALOIDS},
  author = {G.K. Mukusheva and Madina R. Aliyeva and Marzhan KAIYRBAYEVA and A.S. Mazhitov},
  journal = {Kimyo va kimyo texnologiyasi},
  year = {2024},
  volume = {2023},
  number = {2},
  doi = {10.70189/1992-9498.1591},
  url = {https://doi.org/10.70189/1992-9498.1591}
}

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