Antitumor and radiation-sensitizing effects of К-26

Askar Ibragimov, Z. M. Yenikeyeva, N. A. Agzamova, B. T. Madiyorov, B. B. Usmanov, A. I. Amonov, Junior researcher Respublika ixtisoslashtirilgan onkologiya va radiologiya ilmiy-amaliy tibbiyot markazi

Илм-фан ва инновацион ривожланиш · 2019-yil

Annotatsiya

The new colchicine derivative ‘K-26’ manifested both high cytotoxic activity in vitro at the National Cancer Institute of the USA (NCI) and high antitumor activity in a number of transplanted animal tumors. The high antitumor activity of the K-26, as well as its further study as a radiation sensitizer, suggests the study of the alkylating action (effect on DNA and RNA synthesis, on internucleosomal degradation and DNA fragmentation), impact on topoisomerase II activity and drug resistance as well as mitotic activity and induction of CFU. The study showed that K-26 inhibits DNA synthesis, the activity of topoisomerases and MDR2. It stimulates p53, which explains its high antitumor and mitotic effect, leading to the synchronization of cell division and radiation-sensitizing activity. Stimulation of CFEC, which ensures the formation of hematopoietic and immune cells, can protect the body from its intense cytotoxic effect.

Maqola ma’lumotlari
MualliflarAskar Ibragimov, Z. M. Yenikeyeva, N. A. Agzamova, B. T. Madiyorov, B. B. Usmanov, A. I. Amonov, Junior researcher Respublika ixtisoslashtirilgan onkologiya va radiologiya ilmiy-amaliy tibbiyot markazi
JurnalИлм-фан ва инновацион ривожланиш
NashriyotИнновацион ривожланиш вазирлиги
ISSN2181-9637, 2181-4317
Nashr sanasi2019-10-30
Jild2
Son5
Betlar35-43
TilIngliz
DOI10.36522/2181-9637-2019-5-5
Indeksga qo‘shilgan2026-09-02

DOI: 10.36522/2181-9637-2019-5-5 · Maqolaning asl sahifasi

Iqtibos keltirish

APAAskar Ibragimov, Z. M. Yenikeyeva, N. A. Agzamova, B. T. Madiyorov, B. B. Usmanov, A. I. Amonov, & Junior researcher Respublika ixtisoslashtirilgan onkologiya va radiologiya ilmiy-amaliy tibbiyot markazi (2019). ANTITUMOR AND RADIATION-SENSITIZING EFFECTS OF К-26. Илм-фан ва инновацион ривожланиш, 2(5), 35-43. https://doi.org/10.36522/2181-9637-2019-5-5
GOST (OAK)Askar Ibragimov va b. ANTITUMOR AND RADIATION-SENSITIZING EFFECTS OF К-26 // Илм-фан ва инновацион ривожланиш. – 2019. – T. 2, № 5. – P. 35-43. – DOI: 10.36522/2181-9637-2019-5-5.
MLAAskar Ibragimov, Z. M. Yenikeyeva, N. A. Agzamova, B. T. Madiyorov, B. B. Usmanov, A. I. Amonov, and Junior researcher Respublika ixtisoslashtirilgan onkologiya va radiologiya ilmiy-amaliy tibbiyot markazi. “ANTITUMOR AND RADIATION-SENSITIZING EFFECTS OF К-26.” Илм-фан ва инновацион ривожланиш, 2(5), 35-43, 2019. https://doi.org/10.36522/2181-9637-2019-5-5
ChicagoAskar Ibragimov, Z. M. Yenikeyeva, N. A. Agzamova, B. T. Madiyorov, B. B. Usmanov, A. I. Amonov, and Junior researcher Respublika ixtisoslashtirilgan onkologiya va radiologiya ilmiy-amaliy tibbiyot markazi. “ANTITUMOR AND RADIATION-SENSITIZING EFFECTS OF К-26.” Илм-фан ва инновацион ривожланиш, 2(5), 35-43 (2019). https://doi.org/10.36522/2181-9637-2019-5-5
HarvardAskar Ibragimov, Z. M. Yenikeyeva, N. A. Agzamova, B. T. Madiyorov, B. B. Usmanov, A. I. Amonov, and Junior researcher Respublika ixtisoslashtirilgan onkologiya va radiologiya ilmiy-amaliy tibbiyot markazi (2019) ‘ANTITUMOR AND RADIATION-SENSITIZING EFFECTS OF К-26’, Илм-фан ва инновацион ривожланиш, 2(5), 35-43. https://doi.org/10.36522/2181-9637-2019-5-5
BibTeX
@article{askaribragimov2019,
  title = {ANTITUMOR AND RADIATION-SENSITIZING EFFECTS OF К-26},
  author = {Askar Ibragimov and Z. M. Yenikeyeva and N. A. Agzamova and B. T. Madiyorov and B. B. Usmanov and A. I. Amonov and Junior researcher  Respublika ixtisoslashtirilgan onkologiya va radiologiya ilmiy-amaliy tibbiyot markazi},
  journal = {Илм-фан ва инновацион ривожланиш},
  year = {2019},
  volume = {2},
  number = {5},
  pages = {35-43},
  doi = {10.36522/2181-9637-2019-5-5},
  url = {https://doi.org/10.36522/2181-9637-2019-5-5}
}

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