Design and synthesis of 4,6-DISUBSTITUTED quinazoline derivatives as janus kinase inhibitors

Sh. Gaybullaev, Y. Takhirov, K. Zohidov, Chao Niu, Kh. Bozorov

Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi · 2026-yil

Annotatsiya

Janus kinases (JAKs) are recognized as important molecular targets in targeted therapy, and their inhibitors are widely used for the treatment of various autoimmune and inflammatory diseases. Although several JAK inhibitors have been approved by the U.S. Food and Drug Administration (FDA), the development of new compounds with improved selectivity and reduced toxicity remains highly relevant. In this study, a series of novel 4,6-disubstituted quinazoline derivatives were designed using a scaffold-hopping approach, and their targeted synthesis was successfully accomplished, providing a promising basis for the development of more effective JAK inhibitors.

Maqola ma’lumotlari
MualliflarSh. Gaybullaev, Y. Takhirov, K. Zohidov, Chao Niu, Kh. Bozorov
JurnalSamarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi
NashriyotСамарқанд давлат университети
ISSN2091-5446, 2181-1296
Nashr sanasi2026-01-01
Jild1
Son1
Betlar37-43
TilIngliz
Ilmiy sohaKimyo
DOI10.59251/2181-3973.2025.v1.138.1.3745
Indeksga qo‘shilgan2026-09-02

DOI: 10.59251/2181-3973.2025.v1.138.1.3745 · Maqolaning asl sahifasi

Ilmiy soha

Kimyo

Iqtibos keltirish

APASh. Gaybullaev, Y. Takhirov, K. Zohidov, Chao Niu, & Kh. Bozorov (2026). DESIGN AND SYNTHESIS OF 4,6-DISUBSTITUTED QUINAZOLINE DERIVATIVES AS JANUS KINASE INHIBITORS. Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi, 1(1), 37-43. https://doi.org/10.59251/2181-3973.2025.v1.138.1.3745
GOST (OAK)Sh. Gaybullaev va b. DESIGN AND SYNTHESIS OF 4,6-DISUBSTITUTED QUINAZOLINE DERIVATIVES AS JANUS KINASE INHIBITORS // Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi. – 2026. – T. 1, № 1. – P. 37-43. – DOI: 10.59251/2181-3973.2025.v1.138.1.3745.
MLASh. Gaybullaev, Y. Takhirov, K. Zohidov, Chao Niu, and Kh. Bozorov. “DESIGN AND SYNTHESIS OF 4,6-DISUBSTITUTED QUINAZOLINE DERIVATIVES AS JANUS KINASE INHIBITORS.” Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi, 1(1), 37-43, 2026. https://doi.org/10.59251/2181-3973.2025.v1.138.1.3745
ChicagoSh. Gaybullaev, Y. Takhirov, K. Zohidov, Chao Niu, and Kh. Bozorov. “DESIGN AND SYNTHESIS OF 4,6-DISUBSTITUTED QUINAZOLINE DERIVATIVES AS JANUS KINASE INHIBITORS.” Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi, 1(1), 37-43 (2026). https://doi.org/10.59251/2181-3973.2025.v1.138.1.3745
HarvardSh. Gaybullaev, Y. Takhirov, K. Zohidov, Chao Niu, and Kh. Bozorov (2026) ‘DESIGN AND SYNTHESIS OF 4,6-DISUBSTITUTED QUINAZOLINE DERIVATIVES AS JANUS KINASE INHIBITORS’, Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi, 1(1), 37-43. https://doi.org/10.59251/2181-3973.2025.v1.138.1.3745
BibTeX
@article{shgaybullaev2026,
  title = {DESIGN AND SYNTHESIS OF 4,6-DISUBSTITUTED QUINAZOLINE DERIVATIVES AS JANUS KINASE INHIBITORS},
  author = {Sh. Gaybullaev and Y. Takhirov and K. Zohidov and Chao Niu and Kh. Bozorov},
  journal = {Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi},
  year = {2026},
  volume = {1},
  number = {1},
  pages = {37-43},
  doi = {10.59251/2181-3973.2025.v1.138.1.3745},
  url = {https://doi.org/10.59251/2181-3973.2025.v1.138.1.3745}
}

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