Pathomorphological changes in the liver under the influence of brucellosis in an immunized experimental rabbit model

Yusupov Akmal Pulatovich, Kuziyev Otabek Jurakulovich

Klinik fanlar yilnomasi · 2026-yil

Annotatsiya

Pathomorphological changes in the liver under the influence of the live vaccine of Brucella abortus 19 strain were studied in an immunized experimental rabbit model. 12 rabbits (weighing 3.0–3.5 kg) were divided into 4 groups and immunized four times using different schemes (with and without incomplete Freund’s adjuvant). Histological examination of the liver (hematoxylin-eosin staining) showed focal lympho-histiocytic infiltrates, microgranulomas, activation of Kupffer cells, hepatocyte vacuolization, and an increase in the proportion of binucleated hepatocytes (up to 25–35%). These changes confirm the immunogenicity of the Brucella abortus 19 strain and the leading role of the liver in the pathogenesis of brucellosis.

Maqola ma’lumotlari
MualliflarYusupov Akmal Pulatovich, Kuziyev Otabek Jurakulovich
JurnalKlinik fanlar yilnomasi
NashriyotБухоро давлат тиббиёт институти
ISSN2025-2026, 0009-0006
Nashr sanasi2026-05-02
Jild3
Son1/1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

Brucella abortus 19, brucellosis, immunization, strain, Brucella abortus 19, бруцеллез, иммунизация, штамм, Brucella abortus 19, brutsellyoz, immunizatsiya, shtamm

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAYusupov Akmal Pulatovich, & Kuziyev Otabek Jurakulovich (2026). PATHOMORPHOLOGICAL CHANGES IN THE LIVER UNDER THE INFLUENCE OF BRUCELLOSIS IN AN IMMUNIZED EXPERIMENTAL RABBIT MODEL. Klinik fanlar yilnomasi, 3(1/1). https://tadqiqot.uz/index.php/spjacd/article/view/13642
GOST (OAK)Yusupov Akmal Pulatovich, Kuziyev Otabek Jurakulovich PATHOMORPHOLOGICAL CHANGES IN THE LIVER UNDER THE INFLUENCE OF BRUCELLOSIS IN AN IMMUNIZED EXPERIMENTAL RABBIT MODEL // Klinik fanlar yilnomasi. – 2026. – T. 3, № 1/1.
MLAYusupov Akmal Pulatovich, and Kuziyev Otabek Jurakulovich. “PATHOMORPHOLOGICAL CHANGES IN THE LIVER UNDER THE INFLUENCE OF BRUCELLOSIS IN AN IMMUNIZED EXPERIMENTAL RABBIT MODEL.” Klinik fanlar yilnomasi, 3(1/1), 2026. https://tadqiqot.uz/index.php/spjacd/article/view/13642
ChicagoYusupov Akmal Pulatovich, and Kuziyev Otabek Jurakulovich. “PATHOMORPHOLOGICAL CHANGES IN THE LIVER UNDER THE INFLUENCE OF BRUCELLOSIS IN AN IMMUNIZED EXPERIMENTAL RABBIT MODEL.” Klinik fanlar yilnomasi, 3(1/1) (2026). https://tadqiqot.uz/index.php/spjacd/article/view/13642
HarvardYusupov Akmal Pulatovich, and Kuziyev Otabek Jurakulovich (2026) ‘PATHOMORPHOLOGICAL CHANGES IN THE LIVER UNDER THE INFLUENCE OF BRUCELLOSIS IN AN IMMUNIZED EXPERIMENTAL RABBIT MODEL’, Klinik fanlar yilnomasi, 3(1/1). https://tadqiqot.uz/index.php/spjacd/article/view/13642
BibTeX
@article{yusupovakmalpulatovich2026,
  title = {PATHOMORPHOLOGICAL CHANGES IN THE LIVER UNDER THE INFLUENCE OF BRUCELLOSIS IN AN IMMUNIZED EXPERIMENTAL RABBIT MODEL},
  author = {Yusupov Akmal Pulatovich and Kuziyev Otabek Jurakulovich},
  journal = {Klinik fanlar yilnomasi},
  year = {2026},
  volume = {3},
  number = {1/1},
  url = {https://tadqiqot.uz/index.php/spjacd/article/view/13642}
}

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