RESULTS OF USE OF IRREVERSIBLE ELECTROPORATION IN ADENOTONSILLAR HYPERTROPHY

Khudayberganov U.R.

Журнал медицина и инновации · 2026-yil

Annotatsiya

Irreversible electroporation (IRE) is a novel non-thermal tissue ablation technology. The objective of this study was to evaluate the safety and efficacy of IRE in the treatment of adenotonsillar hypertrophy in children.Methods: In this prospective, before- and-after study conducted at an academic medical center, 12 children aged 5-13 years with adenoid or adenotonsillar hypertrophy were enrolled. Eight patients underwent adenotonsillar ablation and 4 adenoid ablation. All procedures were performed under general anesthesia. IRE was applied to the tonsils and/or adenoids using the ENTire TM system. Postoperative pain was assessed daily for one week using the Wong-Baker FACES Pain Rating Scale. Quality-of-life outcomes were evaluated using the Obstructive Sleep Apnea (OSA-18) questionnaire and the Pediatric Sleep Questionnaire - Sleep-Related Breathing Disorder scale (PSQ-SRBD) questionnaire at baseline and 1-month post-procedure. Tonsillar size was assessed using the Brodsky grading scale. Results: The mean procedure time was 12 minutes 15 seconds ± 4 minutes 27 seconds, with no intraoperative or postoperative bleeding observed. Postoperative pain on day 1 ranged from 2 to 5 (3.0 ± 0.95) and resolved completely (score 0) in all patients by day 7. At baseline, the OSA-18 score ranged from 3.0 to 5.2 (4.11 ±0.59), the PSQ-SRBD score ranged from 0.55 to 0.86 (0.60±0.11), and the mean Brodsky grade was 3.2 ± 0.4. At 1-month post-procedure, OSA- 18 score decreased to a range of 1.0 to 1.22 (1.04 ±0.07 ; p<0.001), and the PSQ-SRBD score decreased to a range of 0.00 to 0.09 (0.04 ± 0.04 ; p<0.001). Among the 8 patients who underwent tonsillar ablation, the Brodsky grade scale decreased to 1.3 ± 0.5 (p<0.001). Discussion: This preliminary study is the first to evaluate IRE technology for non-thermal adenotonsillar tissue ablation in pediatric patients. The procedure was brief, associated with less postoperative pain compared to standard treatment, and was not complicated by bleeding. In the short term, tonsillar size was reduced and clinical scores of obstructive symptoms improved.

Maqola ma’lumotlari
MualliflarKhudayberganov U.R.
JurnalЖурнал медицина и инновации
Nashr sanasi2026-04-29
Jild1
Son21
Betlar287-292
TilRus

Kalit so‘zlar

reversible electroporation, adenotonsillar hypertrophy, tonsillectomy.

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