Clinical and microbiological characteristics of patients with demodicosis and concomitant rosacea

Rustamova Madinabonu Sirojiddinovna, Narzikulov Rustam Mardonovich, Рустамова Мадинабону Сирожиддиновна, Нарзикулов Рустам Мардонович, Rustamova Madinabonu Sirojiddinovna, Narzikulov Rustam Mardonovich

Research Focus · 2026-yil

Annotatsiya

Relevance. Demodicosis, especially in combination with rosacea, represents a significant clinical problem because of the intensification of inflammatory manifestations, pronounced erythema, papulopustular elements and resistance to therapy. Modern studies show that an increased density of Demodex spp. and pronounced skin dysbiosis intensify immune-inflammatory reactions and aggravate the course of the disease. Despite the high prevalence and the growing number of observations, the comprehensive clinical and microbiological features of such patients have been insufficiently studied, which determines the need for further research to optimise diagnosis and the choice of effective therapeutic approaches. Aim of the study. To carry out a comprehensive clinical and microbiological characterisation of patients with demodicosis of the facial skin and concomitant rosacea in order to identify the factors that determine the severity of clinical manifestations and the features of microbial dysbiosis. Materials and methods. A cross-sectional comparative study of the «case–control» type was carried out, including 86 patients: the main group — 46 patients with demodicosis in combination with clinically confirmed rosacea, and the control group — 40 patients with isolated demodicosis. The severity of erythema (IGA Rosacea Severity Score), of inflammatory elements (IGA) and of subjective symptoms (VAS), the density of Demodex invasion (SSSB, individuals/cm²), the frequency of isolation and the microbial load of the main microorganisms (Staphylococcus epidermidis, Cutibacterium acnes, Bacillus spp., gram-negative bacteria), as well as polymicrobial colonisation, were assessed. Statistical analysis included Student's t-test, the χ² test and Pearson correlation analysis (p < 0.05). Results. Patients of the main group showed more pronounced erythema (3.1 ± 0.6 versus 1.8 ± 0.5 points; p < 0.001), a greater density of Demodex invasion (13.2 ± 3.4 versus 8.1 ± 2.7 individuals/cm²; p < 0.001) and more intense subjective symptoms. The frequency of detection of S. epidermidis, C. acnes, Bacillus spp. and gram-negative bacteria, as well as their microbial load and polymicrobial colonisation, were significantly higher when demodicosis was combined with rosacea. Significant correlations were established between the density of Demodex and the severity of erythema, papulopustular elements and burning, as well as with colonisation by S. epidermidis and C. acnes and with polymicrobial colonisation. Conclusion. The combination of demodicosis with rosacea is accompanied by a more severe clinical course and pronounced skin dysbiosis caused by the synergistic influence of a high load of Demodex spp. and opportunistic microbiota. The data obtained substantiate the need for a multimodal therapeutic approach that takes into account the parasitic, microbial and immune-inflammatory components of pathogenesis.

Maqola ma’lumotlari
MualliflarRustamova Madinabonu Sirojiddinovna, Narzikulov Rustam Mardonovich, Рустамова Мадинабону Сирожиддиновна, Нарзикулов Рустам Мардонович, Rustamova Madinabonu Sirojiddinovna, Narzikulov Rustam Mardonovich
JurnalResearch Focus
NashriyotВетеринария ИТИ ва “Илм-фан ва инновациялар академияси” МЧЖ
ISSN2181-3833
Nashr sanasi2026-01-05
Jild4
Son12
Betlar313-320
TilIngliz
Ilmiy sohaVeterinariya
DOI10.66073/researchfocus.v4i12.1944
Indeksga qo‘shilgan2026-09-12

DOI: 10.66073/researchfocus.v4i12.1944 · Maqolaning asl sahifasi

Kalit so‘zlar

демодекоз, розацеа, Demodex folliculorum, микробиом кожи, дисбиоз, Staphylococcus epidermidis, Cutibacterium acnes, клинико-микробиологические характеристики, demodekoz, rozatsea, Demodex folliculorum, teri mikrobiomi, disbioz, Staphylococcus epidermidis, Cutibacterium acnes, klinik-mikrobiologik tavsiflar, demodicosis, rosacea, Demodex folliculorum, skin microbiome, dysbiosis, Staphylococcus epidermidis, Cutibacterium acnes, clinical and microbiological characteristics

Ilmiy soha

Veterinariya

Iqtibos keltirish

APARustamova Madinabonu Sirojiddinovna, Narzikulov Rustam Mardonovich, Рустамова Мадинабону Сирожиддиновна, Нарзикулов Рустам Мардонович, Rustamova Madinabonu Sirojiddinovna, & Narzikulov Rustam Mardonovich (2026). CLINICAL AND MICROBIOLOGICAL CHARACTERISTICS OF PATIENTS WITH DEMODICOSIS AND CONCOMITANT ROSACEA. Research Focus, 4(12), 313-320. https://doi.org/10.66073/researchfocus.v4i12.1944
GOST (OAK)Rustamova Madinabonu Sirojiddinovna va b. CLINICAL AND MICROBIOLOGICAL CHARACTERISTICS OF PATIENTS WITH DEMODICOSIS AND CONCOMITANT ROSACEA // Research Focus. – 2026. – T. 4, № 12. – P. 313-320. – DOI: 10.66073/researchfocus.v4i12.1944.
MLARustamova Madinabonu Sirojiddinovna, Narzikulov Rustam Mardonovich, Рустамова Мадинабону Сирожиддиновна, Нарзикулов Рустам Мардонович, Rustamova Madinabonu Sirojiddinovna, and Narzikulov Rustam Mardonovich. “CLINICAL AND MICROBIOLOGICAL CHARACTERISTICS OF PATIENTS WITH DEMODICOSIS AND CONCOMITANT ROSACEA.” Research Focus, 4(12), 313-320, 2026. https://doi.org/10.66073/researchfocus.v4i12.1944
ChicagoRustamova Madinabonu Sirojiddinovna, Narzikulov Rustam Mardonovich, Рустамова Мадинабону Сирожиддиновна, Нарзикулов Рустам Мардонович, Rustamova Madinabonu Sirojiddinovna, and Narzikulov Rustam Mardonovich. “CLINICAL AND MICROBIOLOGICAL CHARACTERISTICS OF PATIENTS WITH DEMODICOSIS AND CONCOMITANT ROSACEA.” Research Focus, 4(12), 313-320 (2026). https://doi.org/10.66073/researchfocus.v4i12.1944
HarvardRustamova Madinabonu Sirojiddinovna, Narzikulov Rustam Mardonovich, Рустамова Мадинабону Сирожиддиновна, Нарзикулов Рустам Мардонович, Rustamova Madinabonu Sirojiddinovna, and Narzikulov Rustam Mardonovich (2026) ‘CLINICAL AND MICROBIOLOGICAL CHARACTERISTICS OF PATIENTS WITH DEMODICOSIS AND CONCOMITANT ROSACEA’, Research Focus, 4(12), 313-320. https://doi.org/10.66073/researchfocus.v4i12.1944
BibTeX
@article{rustamovamadinabonusirojiddinovna2026,
  title = {CLINICAL AND MICROBIOLOGICAL CHARACTERISTICS OF PATIENTS WITH DEMODICOSIS AND CONCOMITANT ROSACEA},
  author = {Rustamova Madinabonu Sirojiddinovna and Narzikulov Rustam Mardonovich and Рустамова Мадинабону Сирожиддиновна and Нарзикулов Рустам Мардонович and Rustamova Madinabonu Sirojiddinovna and Narzikulov Rustam Mardonovich},
  journal = {Research Focus},
  year = {2026},
  volume = {4},
  number = {12},
  pages = {313-320},
  doi = {10.66073/researchfocus.v4i12.1944},
  url = {https://doi.org/10.66073/researchfocus.v4i12.1944}
}

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