The effectiveness of modern topical antioxidants in the prevention of solar dermatitis

Abdurasulovu Nozanin Olimjon qizi, Oripov Rustam Anvarovich, Абдурасулову Нозанин Олимжон кизи, Орипов Рустам Анварович, Abdurasulovu Nozanin Olimjon qizi, Oripov Rustam Anvarovich

Research Focus · 2026-yil

Annotatsiya

Relevance. Solar dermatitis is an inflammatory skin disease that arises as a result of UV-induced oxidative stress and damage to DNA, lipids and proteins, and is accompanied by the activation of pro-inflammatory cytokines. Topical antioxidants capable of neutralising reactive oxygen species and stabilising the barrier structures of the skin are of particular importance in the prevention of photodermatoses. Aim of the study. To assess the clinical effectiveness of modern topical antioxidants (vitamin C, vitamin E, ferulic acid) in the prevention of solar dermatitis in patients with increased photosensitivity. Materials and methods. A prospective comparative study was carried out with 60 patients (Fitzpatrick phototype II–III) allocated to four groups: A — vitamin C 15 %, B — vitamin E 5 %, C — a combination of vitamin C 10 % + vitamin E 2 % + ferulic acid 0.5 %, D — control. The intensity of UV-induced erythema (erythema index), the level of malondialdehyde (MDA), subjective sensations (VAS) and the frequency of episodes of solar dermatitis were assessed. The duration of observation was 8 weeks. Statistical significance was accepted at p < 0.05. Results. The greatest photoprotective effect was observed in group C: the decrease in the erythema index was 47.30 % (p < 0.001), in the MDA level 41 % (p < 0.001) and in VAS symptoms 65 % (p < 0.001). Monotherapy with vitamins C and E provided moderate results (29.40 % and 21.80 % respectively). In the control group the decrease in erythema was 8.20 %. The frequency of episodes of solar dermatitis was minimal in group C — 2 cases versus 11 in the control group (a decrease of 82 %, p < 0.01). The combination of antioxidants demonstrated pronounced synergism and surpassed monotherapy in all indicators. Conclusion. The combination of vitamin C, vitamin E and ferulic acid is the most effective preventive agent against solar dermatitis, providing a marked reduction in inflammation, oxidative stress and subjective discomfort, as well as reducing the frequency of clinical episodes. The preparations have a high safety profile and good tolerability.

Maqola ma’lumotlari
MualliflarAbdurasulovu Nozanin Olimjon qizi, Oripov Rustam Anvarovich, Абдурасулову Нозанин Олимжон кизи, Орипов Рустам Анварович, Abdurasulovu Nozanin Olimjon qizi, Oripov Rustam Anvarovich
JurnalResearch Focus
NashriyotВетеринария ИТИ ва “Илм-фан ва инновациялар академияси” МЧЖ
ISSN2181-3833
Nashr sanasi2026-01-05
Jild4
Son12
Betlar283-290
TilIngliz
Ilmiy sohaVeterinariya
DOI10.66073/researchfocus.v4i12.1940
Indeksga qo‘shilgan2026-09-12

DOI: 10.66073/researchfocus.v4i12.1940 · Maqolaning asl sahifasi

Kalit so‘zlar

Солнечный дерматит, фотодерматит, ультрафиолетовое излучение, оксидативный стресс, антиоксиданты, витамин C, витамин E, феруловая кислота, МДА, erythema index, VAS, фотопротекция, Solar dermatitis, photodermatitis, ultraviolet radiation, oxidative stress, antioxidants, vitamin C, vitamin E, ferulic acid, MDA, erythema index, VAS, photoprotection, Quyosh dermatiti, fotodermatit, ultrabinafsha nurlanish, oksidativ stress, antioksidantlar, vitamin C, vitamin E, ferul kislotasi, MDA, erythema index, VAS, fotoprotektsiya

Ilmiy soha

Veterinariya

Iqtibos keltirish

APAAbdurasulovu Nozanin Olimjon qizi, Oripov Rustam Anvarovich, Абдурасулову Нозанин Олимжон кизи, Орипов Рустам Анварович, Abdurasulovu Nozanin Olimjon qizi, & Oripov Rustam Anvarovich (2026). THE EFFECTIVENESS OF MODERN TOPICAL ANTIOXIDANTS IN THE PREVENTION OF SOLAR DERMATITIS. Research Focus, 4(12), 283-290. https://doi.org/10.66073/researchfocus.v4i12.1940
GOST (OAK)Abdurasulovu Nozanin Olimjon qizi va b. THE EFFECTIVENESS OF MODERN TOPICAL ANTIOXIDANTS IN THE PREVENTION OF SOLAR DERMATITIS // Research Focus. – 2026. – T. 4, № 12. – P. 283-290. – DOI: 10.66073/researchfocus.v4i12.1940.
MLAAbdurasulovu Nozanin Olimjon qizi, Oripov Rustam Anvarovich, Абдурасулову Нозанин Олимжон кизи, Орипов Рустам Анварович, Abdurasulovu Nozanin Olimjon qizi, and Oripov Rustam Anvarovich. “THE EFFECTIVENESS OF MODERN TOPICAL ANTIOXIDANTS IN THE PREVENTION OF SOLAR DERMATITIS.” Research Focus, 4(12), 283-290, 2026. https://doi.org/10.66073/researchfocus.v4i12.1940
ChicagoAbdurasulovu Nozanin Olimjon qizi, Oripov Rustam Anvarovich, Абдурасулову Нозанин Олимжон кизи, Орипов Рустам Анварович, Abdurasulovu Nozanin Olimjon qizi, and Oripov Rustam Anvarovich. “THE EFFECTIVENESS OF MODERN TOPICAL ANTIOXIDANTS IN THE PREVENTION OF SOLAR DERMATITIS.” Research Focus, 4(12), 283-290 (2026). https://doi.org/10.66073/researchfocus.v4i12.1940
HarvardAbdurasulovu Nozanin Olimjon qizi, Oripov Rustam Anvarovich, Абдурасулову Нозанин Олимжон кизи, Орипов Рустам Анварович, Abdurasulovu Nozanin Olimjon qizi, and Oripov Rustam Anvarovich (2026) ‘THE EFFECTIVENESS OF MODERN TOPICAL ANTIOXIDANTS IN THE PREVENTION OF SOLAR DERMATITIS’, Research Focus, 4(12), 283-290. https://doi.org/10.66073/researchfocus.v4i12.1940
BibTeX
@article{abdurasulovunozaninolimjonqizi2026,
  title = {THE EFFECTIVENESS OF MODERN TOPICAL ANTIOXIDANTS IN THE PREVENTION OF SOLAR DERMATITIS},
  author = {Abdurasulovu Nozanin Olimjon qizi and Oripov Rustam Anvarovich and Абдурасулову Нозанин Олимжон кизи and Орипов Рустам Анварович and Abdurasulovu Nozanin Olimjon qizi and Oripov Rustam Anvarovich},
  journal = {Research Focus},
  year = {2026},
  volume = {4},
  number = {12},
  pages = {283-290},
  doi = {10.66073/researchfocus.v4i12.1940},
  url = {https://doi.org/10.66073/researchfocus.v4i12.1940}
}

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