Morphological features of bronchial mucosa remodeling based on a model of bronchiectatic disease

Zhovliyeva M.B., Khamidova F.M.

Ёш олимлар тиббиёт журнали · 2024-yil

Annotatsiya

The study of lung tissue in bronchiectasis in animals is necessary for a deep understanding of the cellular and molecular mechanisms of chronic respiratory diseases and the development of new methods for their diagnosis and therapy. The aim of the study is to study the structural and functional organization of the bronchial mucosa and to identify patterns of inflammation and remodeling of the bronchi in a model of bronchiectasis. The study involved 70 white mongrel male rabbits, the control group consisted of 10 intact animals, the main group consisted of 60 rabbits with a model of chronic inflammation. The lung tissue samples were stained with hematoxylin and eosin, picrofuxin according to Van Gieson and resorcinol–fuchsin according to Weigert. Immunochemical studies included antibodies to Ki–67, Bcl–2, CD3, CD20, CD163, CK5/6 and CK8/18. After 7–12 months, signs of inflammation and tissue destruction, thickening of the bronchial wall were observed. The number of CD3, CD–20, CD–163, Bcl–2 and Ki–67 positive cells increased, reaching a maximum by 12 months. The severity of CD–163 increased by the 9th month. A comprehensive histological and immunohistochemical study revealed the progression of inflammation with activation of the T– and B–dependent immune response and remodeling of the bronchial wall, as well as signs of metaplasia of the bronchial epithelium.

Maqola ma’lumotlari
MualliflarZhovliyeva M.B., Khamidova F.M.
JurnalЁш олимлар тиббиёт журнали
NashriyotТошкент тиббиёт академияси
ISSN2181-3485
Nashr sanasi2024-12-09
Son12
Betlar131-146
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

bronchi, lungs, chronic inflammation, mucous membrane, rabbit.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAZhovliyeva M.B., Khamidova F.M. (2024). MORPHOLOGICAL FEATURES OF BRONCHIAL MUCOSA REMODELING BASED ON A MODEL OF BRONCHIECTATIC DISEASE. Ёш олимлар тиббиёт журнали, (12), 131-146. https://journals.tnmu.uz/index.php/yotj/article/view/874
GOST (OAK)Zhovliyeva M.B., Khamidova F.M. MORPHOLOGICAL FEATURES OF BRONCHIAL MUCOSA REMODELING BASED ON A MODEL OF BRONCHIECTATIC DISEASE // Ёш олимлар тиббиёт журнали. – 2024. – № 12. – P. 131-146.
MLAZhovliyeva M.B., Khamidova F.M. “MORPHOLOGICAL FEATURES OF BRONCHIAL MUCOSA REMODELING BASED ON A MODEL OF BRONCHIECTATIC DISEASE.” Ёш олимлар тиббиёт журнали, (12), 131-146, 2024. https://journals.tnmu.uz/index.php/yotj/article/view/874
ChicagoZhovliyeva M.B., Khamidova F.M. “MORPHOLOGICAL FEATURES OF BRONCHIAL MUCOSA REMODELING BASED ON A MODEL OF BRONCHIECTATIC DISEASE.” Ёш олимлар тиббиёт журнали, (12), 131-146 (2024). https://journals.tnmu.uz/index.php/yotj/article/view/874
HarvardZhovliyeva M.B., Khamidova F.M (2024) ‘MORPHOLOGICAL FEATURES OF BRONCHIAL MUCOSA REMODELING BASED ON A MODEL OF BRONCHIECTATIC DISEASE’, Ёш олимлар тиббиёт журнали, (12), 131-146. https://journals.tnmu.uz/index.php/yotj/article/view/874
BibTeX
@article{zhovliyevambkhamidovafm2024,
  title = {MORPHOLOGICAL FEATURES OF BRONCHIAL MUCOSA REMODELING BASED ON A MODEL OF BRONCHIECTATIC DISEASE},
  author = {Zhovliyeva M.B., Khamidova F.M.},
  journal = {Ёш олимлар тиббиёт журнали},
  year = {2024},
  number = {12},
  pages = {131-146},
  url = {https://journals.tnmu.uz/index.php/yotj/article/view/874}
}

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