BIOLOGICAL ACTIVITY OF 3-AMINO-4-METHYL BENZOIC ACID AND ITS SUPRAMOLECULAR COMPOUND WITH NICKEL TRIETHANOLAMINE COMPLEX

Farrukhbek, Oybek ugli Mamatsabirov, Abbos, Bozor ugli Mambetov, Azizbek, Jovliyev Muxtor o'g'li, Azizbek, Serobov Nizomjonovich, Bakhtiyar, Tulaganovich Ibragimov

Қўқон ДПИ. Илмий хабарлар · 2026-yil

Annotatsiya

A supramolecular nickel(II) complex, bis[triethanolamine- κN,O,O′]nickel(II) bis(3-amino-4-methylbenzoate), [Ni(TEA)2](AMB)2, was synthesized and comprehensively characterized by and single-crystal X-ray diffraction. Antimicrobial assays show that the complex exhibits moderate, broad-spectrum antibacterial activity and performs better than its individual components, though it remains less active than ciprofloxacin. Molecular docking studies predict the strongest binding to Bacillus subtilis, supported by a favourable cavity size and π-π interactions with a porphyrin cofactor.

Maqola ma’lumotlari
MualliflarFarrukhbek, Oybek ugli Mamatsabirov, Abbos, Bozor ugli Mambetov, Azizbek, Jovliyev Muxtor o'g'li, Azizbek, Serobov Nizomjonovich, Bakhtiyar, Tulaganovich Ibragimov
JurnalҚўқон ДПИ. Илмий хабарлар
Nashr sanasi2026-07-13
Jild8
Son6
Betlar78-86
TilIngliz
DOI10.70728/a.series.tab.v08.i06.012

DOI: 10.70728/a.series.tab.v08.i06.012 · Maqolaning asl sahifasi

Kalit so‘zlar

nickel(II)complex, 3-amino-4-methylbenzoate, triethanolamine, synthesis, SCXRD, coordination geometry, antimicrobial activity, molecular docking.

Ilmiy soha

ArxitekturaPedagogikaPsixologiyaSan’atshunoslik

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