This study assesses the activity of autoimmune reactions in adolescent children with HIV encephalopathy of varying severity. According to the results of the study, it was found that in children with HIV encephalopathy, symptomatic neurocognitive impairments are associated with the activation of cellular and humoral immunity - mainly natural killers, apoptosis markers, antibody-producing and reactive lymphocytes. In this regard, a hypothesis was put forward about the role of autoimmune reactions in the formation of HIV encephalopathy. Possible ways of damage to the CNS can be both vasculitis and autoimmune damage to the nervous tissue itself. Based on this hypothesis, during the study, a study was made of the concentration of autoantibodies - Abs to myelin, APA (vasculitis induction), Abs to cell nuclei (ANA) and their components - 1- and 2-stranded DNA.
| Mualliflar | Saidkhodjaeva, S, Majidova, Y, Саидходжаева, С, Маджидова, Ё, Саидходжаева, С, Маджидова, Ё |
|---|---|
| Jurnal | Nevrologiya |
| Nashr sanasi | 2023-04-27 |
| Jild | 1 |
| Son | 3 |
| Betlar | 25-27 |
| Til | Ingliz |
педиатрическая ВИЧ-энцефалопатия, аутоиммунитет, антитела к миелину, антитела к 1-но и 2-х цепочечной ДНК, подростки, нейрокогнитивное расстройство, pediatric HIV encephalopathy, autoimmunity, antibodies to myelin, antibodies to 1 and 2 stranded DNA, adolescents, neurocognitive disorder, педиатрик ОИВ энцефалопатия, аутоиммунитет, миелин антикорлари, 1-ва 2-занжир ДНК антикорлари, ўсмирлар, нейрокогнитив бузилиши
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