Influ ence of pharmacotherapy on function of kidneys and vascular endothelium in experimental ischemic stroke

Rasulova, Kh, Daminov, B, Madjidova, Y, Расулова, Х, Даминов, Б, Маджидова, Ë, Расулова, Х, Даминов, Б, Маджидова, Ë

Nevrologiya · 2023-yil

Annotatsiya

Aim of the study.To assess the degree of endothelial dysfunction and renal function in experimental ischemic stroke (EIS) in rats on the dynamics of pharmacotherapy.Materials and Methods.The subject of experimental studies were 105 adult mongrel white male rats. The object of the study were the serum and urine of rats. The model of cerebral circulation reproduced by temporary clipping of the left common carotid artery. The controls were 20 intact animals. Results. The results indicate to the development of endothelial dysfunction with EIS with the activation of neoangiogenesis in experimental animals. Pharmacotherapy with suksinasol for 7 days caused reduction of the level of ET-1 with respect to the values of untreated animal group and was still significantly higher than control group of rats in 2.5 times. At the same time, the level of VEGf A (vascular endothelial growth factor A) significantly decreased respectively to untreated group of rats in 1.65 times (p<0.01), but was still higher than control values in 1.74 times (p<0.01). development of proteinuria, microalbuminuria and creatininuria in rats with EIS apparently was due to the development of hemodynamic changes in the kidney and glomerular basal membrane permeability, and due to the enhanced excretion of toxins and protein degradation products.Conclusion. The endothelial and renal dysfunctions with activation of neoangiogenesis develop on the model of EIS. Pharmacotherapy corrects the identified changes to some extent. Tivortin and choline alfosceratewere more effective, possibly, because of decrease of hemodynamic disturbances and neurotrophic effects.

Maqola ma’lumotlari
MualliflarRasulova, Kh, Daminov, B, Madjidova, Y, Расулова, Х, Даминов, Б, Маджидова, Ë, Расулова, Х, Даминов, Б, Маджидова, Ë
JurnalNevrologiya
NashriyotЎзбекистон неврологлар ассоциацияси, , Тошкент врачлар малакасини ошириш, институти
ISSN2010-5452
Nashr sanasi2023-04-15
Jild1
Son4
Betlar6-9
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

экспериментальный ишемический инсульт, почки, крысы, сыворотка крови, неоангиогенез, сукцинасол, тивортин, холина альфосцерат, эксперименталишемик инсульт, буйраклар, каламушлар, қон зардоби, неоангиогенез, сукцинасол, тивортин, холин альфосцерати, experimental ischemic stroke, kidneys, rats, blood serum, neoangiogenesis, suktsinasol, tivortin, choline alfoscerate

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APARasulova, Kh, Daminov, B, Madjidova, Y, Расулова, Х, Даминов, Б, Маджидова, Ë, Расулова, Х, Даминов, Б, & Маджидова, Ë (2023). Influ ence of pharmacotherapy on function of kidneys and vascular endothelium in experimental ischemic stroke. Nevrologiya, 1(4), 6-9. https://inlibrary.uz/index.php/nevrologiya/article/view/19210
GOST (OAK)Rasulova, Kh va b. Influ ence of pharmacotherapy on function of kidneys and vascular endothelium in experimental ischemic stroke // Nevrologiya. – 2023. – T. 1, № 4. – P. 6-9.
MLARasulova, Kh, Daminov, B, Madjidova, Y, Расулова, Х, Даминов, Б, Маджидова, Ë, Расулова, Х, Даминов, Б, and Маджидова, Ë. “Influ ence of pharmacotherapy on function of kidneys and vascular endothelium in experimental ischemic stroke.” Nevrologiya, 1(4), 6-9, 2023. https://inlibrary.uz/index.php/nevrologiya/article/view/19210
ChicagoRasulova, Kh, Daminov, B, Madjidova, Y, Расулова, Х, Даминов, Б, Маджидова, Ë, Расулова, Х, Даминов, Б, and Маджидова, Ë. “Influ ence of pharmacotherapy on function of kidneys and vascular endothelium in experimental ischemic stroke.” Nevrologiya, 1(4), 6-9 (2023). https://inlibrary.uz/index.php/nevrologiya/article/view/19210
HarvardRasulova, Kh, Daminov, B, Madjidova, Y, Расулова, Х, Даминов, Б, Маджидова, Ë, Расулова, Х, Даминов, Б, and Маджидова, Ë (2023) ‘Influ ence of pharmacotherapy on function of kidneys and vascular endothelium in experimental ischemic stroke’, Nevrologiya, 1(4), 6-9. https://inlibrary.uz/index.php/nevrologiya/article/view/19210
BibTeX
@article{rasulovakh2023,
  title = {Influ ence of pharmacotherapy on function of kidneys and vascular endothelium in experimental ischemic stroke},
  author = {Rasulova, Kh and Daminov, B and Madjidova, Y and Расулова, Х and Даминов, Б and Маджидова, Ë and Расулова, Х and Даминов, Б and Маджидова, Ë},
  journal = {Nevrologiya},
  year = {2023},
  volume = {1},
  number = {4},
  pages = {6-9},
  url = {https://inlibrary.uz/index.php/nevrologiya/article/view/19210}
}

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