Acromegaly is a neuroendocrine disease caused by chronic excess secretion of STH in individuals with complete physiological growth and characterizing pathological disproportionate periosteal growth of bones, cartilage, soft tissues, internal organs, as well as a violation of the functional state of the cardiovascular, pulmonary system, peripheral glands , different types of metabolism. The prevalence of acromegaly throughout the world is about 4600 cases per million population, while about 116.9 new cases per million are registered annually. In Uzbekistan, the incidence of acromegaly is approximately 1.6 per 100,000 population. The manifestations of acromegaly can be quite insidious, and, despite the improvement and introduction of modern diagnostic methods, there is a significant delay in timely diagnosis, contributing to adverse consequences and worsening the prognosis of the disease. According to various scientific and medical studies, the time from the moment the first symptoms of acromegaly appear to the diagnosis varies from 3 to 25 years. Gonadal complications are observed in most patients with acromegaly. The frequency of menstrual irregularities in patients with acromegaly is about 40-84% and is due to the development of normo- or hypogonadotropic hypogonadism against the background of hyperprolactinemia due to a tumor, as well as due to the direct effects of growth hormone (STH) and insulin-like growth factor-1 ( IGF-1) on the reproductive system. The great influence of somatotropic hormone and insulin-like growth factor 1 of the type on the development of the uterus, folliculogenesis and ovarian steroidogenesis was established. In this regard, the study of the role of somatotropic hormone and IGF-1 hypersecretion on the reproductive system is a key point for its assessment.
| Mualliflar | Khalimova, Z., Kurbanova , S., Nasyrova, Kh., Халимова, З., Курбанова, С., Насырова, Х., Xalimova, Z., Kurbanova, S., Nosirova, X. |
|---|---|
| Jurnal | Жамият ва инновациялар / Общество и инновации / Society and innovations |
| Nashr sanasi | 2021-12-14 |
| Jild | 2 |
| Son | 10/S |
| Betlar | 577-587 |
| Til | Rus |
| DOI | 10.47689/2181-1415-vol2-iss10/s-pp577-587 |
DOI: 10.47689/2181-1415-vol2-iss10/s-pp577-587 · Maqolaning asl sahifasi
акромегалия, гормон роста, ИФР-1, СПКЯ, миома матки, гиперплазия эндометрия, рак эндометрия, acromegaly, growth hormone, IGF-1, PCOS, uterine myoma, endometrial hyperplasia, endometrial cancer, akromegali, o'sish gormoni, IGF-1, bachadon miomasi, endometriyal giperplaziya, endometrium saratoni
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