This study introduces novel approaches against multidrug-resistant bacteria using nanozymes and phosphatase inhibitors. Beet-derived SN-CNPs exhibited robust phosphatase-like activity and selectively disrupted bacterial membranes, while sodium orthovanadate (SOV) inhibited phosphatases essential for cell wall synthesis, exerting bactericidal effects. Combined application of SN-CNPs and SOV enhanced antimicrobial efficacy against E. coli and L. lactis, highlighting a synergistic mechanism. The findings underscore phosphatase-centered strategies as a paradigm shift from conventional ROS-dependent therapies and open new avenues for multi-targeted antimicrobial interventions.
| Mualliflar | Benassi, Enrico, Fan, Haiyan |
|---|---|
| Jurnal | Товарлар кимёси ва халқ табобати |
| Nashr sanasi | 2025-11-11 |
| Jild | 4 |
| Son | 3 |
| Betlar | 68-77 |
| Til | O‘zbek |
| DOI | 10.55475/jcgtm/vol4.iss3.2025.530 |
DOI: 10.55475/jcgtm/vol4.iss3.2025.530 · Maqolaning asl sahifasi
multidrug-resistant bacteria, nanozymes, phosphatase inhibitor, SN-CNP, SOV, synergy, antimicrobial therapy, множественная лекарственная устойчивость, нанозимы, ингибитор фосфатазы, SN-CNP, SOV, синергия, антимикробная терапия
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