The role of integrative MRI in diagnosing pathological processes in the brain parenchyma

NISHANOVA Yulduz Khatamovna, ILKHAMOV Dilshod Farkhadovich, USMONOV Bekzodkhuja Toshpulatovich, YORQINOV Akbar Sharofiddinovich, TOIROVA Dilafruz Ravshanovna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

Introduction: Pathological processes within the brain parenchyma represent one of the leading causes of neurological impairment and mortality. The diverse nature of these pathologies and their asymptomatic progression in early stages significantly complicate their diagnosis. Objective: To determine the prognostic value of quantitative parameters in the differential diagnosis of pathological processes in the brain parenchyma based on modern magnetic resonance imaging (MRI) protocols. Materials and Methods: A prospective cohort study was conducted from 2021 to 2025 involving 107 patients. All subjects underwent MRI using a standard protocol (T1-WI, T2-WI, FLAIR, DWI, SWI). Gadolinium-based contrast agents were administered in 92% of cases. MR spectroscopy was performed in 23 patients, MR perfusion in 19 patients, and diffusion tensor imaging (DTI) in 13 patients. Quantitative analysis included calculation of ADC (Apparent Diffusion Coefficient), rCBV (relative Cerebral Blood Volume), and metabolite ratios. Results: The overall diagnostic accuracy of MRI was 97.3%. ADC values enabled differentiation of metastatic lesions (0.72 ± 0.08 ×10⁻³ mm²/s) from glioblastoma multiforme (0.83 ± 0.11 ×10⁻³ mm²/s) with a sensitivity of 94.2% (p<0.001). rCBV values were significantly higher in meningiomas (8.3 ± 2.1) compared to gliomas (5.2 ± 1.8) (p<0.01). An elevated Cho/NAA ratio greater than 2.5 on MR spectroscopy showed a diagnostic accuracy of 45.7% as a prognostic indicator of malignant progression. Conclusion: A multiparametric MRI approach provides a reproducible and quantitative methodology for the differential diagnosis of pathological processes in the brain parenchyma. Quantitative MRI parameters offer the potential to establish morphofunctional correlations and to develop individualized prognostic models.

Maqola ma’lumotlari
MualliflarNISHANOVA Yulduz Khatamovna, ILKHAMOV Dilshod Farkhadovich, USMONOV Bekzodkhuja Toshpulatovich, YORQINOV Akbar Sharofiddinovich, TOIROVA Dilafruz Ravshanovna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-01-13
Jild10
Son6
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

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Kalit so‘zlar

магнитно-резонансная томография, нейровизуализация, диффузионно- тензорная визуализация, МР-спектроскопия, перфузионно-взвешенная визуализация, количественная нейрорадиология, magnetic resonance imaging, neuroimaging, diffusion tensor imaging, MR spectroscopy, perfusion-weighted imaging, quantitative neuroradiology, magnit-rezonans tomografiya, neyrovizualizatsiya, diffuzion tensor tasvirlash, MR- spektroskopiya, perfuziya vazog'irligi, kvantitativ neyroradiologiya

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Iqtibos keltirish

APANISHANOVA Yulduz Khatamovna, ILKHAMOV Dilshod Farkhadovich, USMONOV Bekzodkhuja Toshpulatovich, YORQINOV Akbar Sharofiddinovich, & TOIROVA Dilafruz Ravshanovna (2026). THE ROLE OF INTEGRATIVE MRI IN DIAGNOSING PATHOLOGICAL PROCESSES IN THE BRAIN PARENCHYMA. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6). https://tadqiqot.uz/index.php/biomedicine/article/view/13135
GOST (OAK)NISHANOVA Yulduz Khatamovna va b. THE ROLE OF INTEGRATIVE MRI IN DIAGNOSING PATHOLOGICAL PROCESSES IN THE BRAIN PARENCHYMA // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 10, № 6.
MLANISHANOVA Yulduz Khatamovna, ILKHAMOV Dilshod Farkhadovich, USMONOV Bekzodkhuja Toshpulatovich, YORQINOV Akbar Sharofiddinovich, and TOIROVA Dilafruz Ravshanovna. “THE ROLE OF INTEGRATIVE MRI IN DIAGNOSING PATHOLOGICAL PROCESSES IN THE BRAIN PARENCHYMA.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/13135
ChicagoNISHANOVA Yulduz Khatamovna, ILKHAMOV Dilshod Farkhadovich, USMONOV Bekzodkhuja Toshpulatovich, YORQINOV Akbar Sharofiddinovich, and TOIROVA Dilafruz Ravshanovna. “THE ROLE OF INTEGRATIVE MRI IN DIAGNOSING PATHOLOGICAL PROCESSES IN THE BRAIN PARENCHYMA.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/13135
HarvardNISHANOVA Yulduz Khatamovna, ILKHAMOV Dilshod Farkhadovich, USMONOV Bekzodkhuja Toshpulatovich, YORQINOV Akbar Sharofiddinovich, and TOIROVA Dilafruz Ravshanovna (2026) ‘THE ROLE OF INTEGRATIVE MRI IN DIAGNOSING PATHOLOGICAL PROCESSES IN THE BRAIN PARENCHYMA’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6). https://tadqiqot.uz/index.php/biomedicine/article/view/13135
BibTeX
@article{nishanovayulduzkhatamovna2026,
  title = {THE ROLE OF INTEGRATIVE MRI IN DIAGNOSING PATHOLOGICAL PROCESSES IN THE BRAIN PARENCHYMA},
  author = {NISHANOVA Yulduz Khatamovna and ILKHAMOV Dilshod Farkhadovich and USMONOV Bekzodkhuja Toshpulatovich and YORQINOV Akbar Sharofiddinovich and TOIROVA Dilafruz Ravshanovna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {10},
  number = {6},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13135}
}

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