Therapeutic application of plasmapheresis in surgical management of acute benign cholangitis

ABDIKADIROV Ulugbek Abdiqaxramonovich, KADIROV Rustam Nodirovich, KURBANIYAZOV Zafar Bobojonovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2025-yil

Annotatsiya

This research evaluates the therapeutic efficacy of plasmapheresis (PF) integrated into the surgical treatment protocol for acute benign cholangitis. The study encompassed 17 patients who underwent a novel therapeutic approach combining plasmapheresis with indirect electrochemical detoxification, utilizing sodium hypochlorite solution and ozonation for autoplasma recovery. The implementation of plasmapheresis, alongside comprehensive pharmacological intervention, demonstrated significant clinical efficacy in patients presenting with cholangitis complicated by hepatic insufficiency. Notable improvements in endotoxemia parameters and hepatic function were observed within 48-72 hours post-intervention. Specifically, aspartate aminotransferase (AsAT) levels decreased from 1.4±0.05 to 0.5±0.02 mmol/l, while alanine aminotransferase (AlAT) reduced from 1.1±0.06 to 0.37±0.01 mmol/l. The incorporation of plasmapheresis with antihypoxant and antioxidant therapy yielded substantial reductions in oxidative stress markers and endotoxemia parameters. By day 4, diene conjugates (DC) decreased to 1.3±0.03 opt.pg/ml, malondialdehyde (MDA) levels reduced to 3.2±0.21 mmol/mg, and blood lactate concentrations diminished to 2.4±0.6 mmol, indicating significant improvement in the patients' metabolic status. These findings suggest that plasmapheresis, when integrated into a comprehensive treatment protocol, represents an effective therapeutic modality for managing acute benign cholangitis, particularly in cases complicated by hepatic dysfunction and endotoxemia.

Maqola ma’lumotlari
MualliflarABDIKADIROV Ulugbek Abdiqaxramonovich, KADIROV Rustam Nodirovich, KURBANIYAZOV Zafar Bobojonovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2025-02-13
Jild9
Son6
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

Острый доброкачественный холангит, плазмаферез, эндотоксемия, печеночная дисфункция, терапевтическая детоксикация, хирургическое лечение, Acute benign cholangitis, plasmapheresis, endotoxemia, hepatic dysfunction, therapeutic detoxification, surgical management, O'tkir xavfsiz xolangit, plazmaferez, endotoksemiya, jigar disfunksiyasi, terapevtik detoksikatsiya, jarrohlik davolash

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAABDIKADIROV Ulugbek Abdiqaxramonovich, KADIROV Rustam Nodirovich, & KURBANIYAZOV Zafar Bobojonovich (2025). THERAPEUTIC APPLICATION OF PLASMAPHERESIS IN SURGICAL MANAGEMENT OF ACUTE BENIGN CHOLANGITIS. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(6). https://tadqiqot.uz/index.php/biomedicine/article/view/10958
GOST (OAK)ABDIKADIROV Ulugbek Abdiqaxramonovich, KADIROV Rustam Nodirovich, KURBANIYAZOV Zafar Bobojonovich THERAPEUTIC APPLICATION OF PLASMAPHERESIS IN SURGICAL MANAGEMENT OF ACUTE BENIGN CHOLANGITIS // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2025. – T. 9, № 6.
MLAABDIKADIROV Ulugbek Abdiqaxramonovich, KADIROV Rustam Nodirovich, and KURBANIYAZOV Zafar Bobojonovich. “THERAPEUTIC APPLICATION OF PLASMAPHERESIS IN SURGICAL MANAGEMENT OF ACUTE BENIGN CHOLANGITIS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(6), 2025. https://tadqiqot.uz/index.php/biomedicine/article/view/10958
ChicagoABDIKADIROV Ulugbek Abdiqaxramonovich, KADIROV Rustam Nodirovich, and KURBANIYAZOV Zafar Bobojonovich. “THERAPEUTIC APPLICATION OF PLASMAPHERESIS IN SURGICAL MANAGEMENT OF ACUTE BENIGN CHOLANGITIS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(6) (2025). https://tadqiqot.uz/index.php/biomedicine/article/view/10958
HarvardABDIKADIROV Ulugbek Abdiqaxramonovich, KADIROV Rustam Nodirovich, and KURBANIYAZOV Zafar Bobojonovich (2025) ‘THERAPEUTIC APPLICATION OF PLASMAPHERESIS IN SURGICAL MANAGEMENT OF ACUTE BENIGN CHOLANGITIS’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(6). https://tadqiqot.uz/index.php/biomedicine/article/view/10958
BibTeX
@article{abdikadirovulugbekabdiqaxramonovich2025,
  title = {THERAPEUTIC APPLICATION OF PLASMAPHERESIS IN SURGICAL MANAGEMENT OF ACUTE BENIGN CHOLANGITIS},
  author = {ABDIKADIROV Ulugbek Abdiqaxramonovich and KADIROV Rustam Nodirovich and KURBANIYAZOV Zafar Bobojonovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2025},
  volume = {9},
  number = {6},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/10958}
}

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