The importance of tumor necrosis factor alpha in the prognosis of breast canser

Urmanbayeva, Dilbarhon, Adhamjonova, Uktamxon, Abdivokhobova, Gulnozakhon, Erkinova, Shoxista

Жанубий оролбўйи тиббиёт журнали · 2026-yil

Annotatsiya

Tumor necrosis factor alpha (TNF-α) is a multifunctional cytokine with a dual role in cancer biology, exhibiting both tumor-promoting and tumor-suppressive effects. This study provides a comprehensive analysis of TNF-α in breast cancer prognosis, integrating molecular, clinical, and translational perspectives. Elevated TNF-α levels are strongly associated with tumor progression, metastasis, and reduced survival rates. Mechanistically, TNF-α activates key oncogenic pathways, including NF-κB, MAPK, and PI3K/Akt. However, under controlled conditions, TNF-α may induce apoptosis in tumor cells. The findings highlight TNF-α as a promising prognostic biomarker and a potential therapeutic target in precision oncology

Maqola ma’lumotlari
MualliflarUrmanbayeva, Dilbarhon, Adhamjonova, Uktamxon, Abdivokhobova, Gulnozakhon, Erkinova, Shoxista
JurnalЖанубий оролбўйи тиббиёт журнали
NashriyotТТА Урганч филиали
ISSN3093-8740, 2012-2021
Nashr sanasi2026-05-12
Jild2
Son2
Betlar112-117
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

TNF-α, breast cancer, prognosis, cytokines, tumor microenvironment

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAUrmanbayeva, Dilbarhon, Adhamjonova, Uktamxon, Abdivokhobova, Gulnozakhon, & Erkinova, Shoxista (2026). THE IMPORTANCE OF TUMOR NECROSIS FACTOR ALPHA IN THE PROGNOSIS OF BREAST CANSER. Жанубий оролбўйи тиббиёт журнали, 2(2), 112-117. http://journal.urdti.uz/index/article/view/584
GOST (OAK)Urmanbayeva, Dilbarhon va b. THE IMPORTANCE OF TUMOR NECROSIS FACTOR ALPHA IN THE PROGNOSIS OF BREAST CANSER // Жанубий оролбўйи тиббиёт журнали. – 2026. – T. 2, № 2. – P. 112-117.
MLAUrmanbayeva, Dilbarhon, Adhamjonova, Uktamxon, Abdivokhobova, Gulnozakhon, and Erkinova, Shoxista. “THE IMPORTANCE OF TUMOR NECROSIS FACTOR ALPHA IN THE PROGNOSIS OF BREAST CANSER.” Жанубий оролбўйи тиббиёт журнали, 2(2), 112-117, 2026. http://journal.urdti.uz/index/article/view/584
ChicagoUrmanbayeva, Dilbarhon, Adhamjonova, Uktamxon, Abdivokhobova, Gulnozakhon, and Erkinova, Shoxista. “THE IMPORTANCE OF TUMOR NECROSIS FACTOR ALPHA IN THE PROGNOSIS OF BREAST CANSER.” Жанубий оролбўйи тиббиёт журнали, 2(2), 112-117 (2026). http://journal.urdti.uz/index/article/view/584
HarvardUrmanbayeva, Dilbarhon, Adhamjonova, Uktamxon, Abdivokhobova, Gulnozakhon, and Erkinova, Shoxista (2026) ‘THE IMPORTANCE OF TUMOR NECROSIS FACTOR ALPHA IN THE PROGNOSIS OF BREAST CANSER’, Жанубий оролбўйи тиббиёт журнали, 2(2), 112-117. http://journal.urdti.uz/index/article/view/584
BibTeX
@article{urmanbayevadilbarhon2026,
  title = {THE IMPORTANCE OF TUMOR NECROSIS FACTOR ALPHA IN THE PROGNOSIS OF BREAST CANSER},
  author = {Urmanbayeva, Dilbarhon and Adhamjonova, Uktamxon and Abdivokhobova, Gulnozakhon and Erkinova, Shoxista},
  journal = {Жанубий оролбўйи тиббиёт журнали},
  year = {2026},
  volume = {2},
  number = {2},
  pages = {112-117},
  url = {http://journal.urdti.uz/index/article/view/584}
}

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