The role of pro-inflammatory and anti-inflammatory cytokines during COVID-19 in patients with chronic ent disease

AMONOV Erkin Inoyatovich, MUSAKHODJAEVA Diloram Abdullaevna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2023-yil

Annotatsiya

Objective: The aim of the study was to evaluate the serum levels of regulatory cytokines in ENT patients hospitalized with moderate and severe COVID-19. Materials and Methods: 84 patients with confirmed coronavirus infection were taken under observation. Among them, 16 (19.04%) patients had a mild course, 44 (52.4%) patients had an average course, and 24 (28.6%) patients had a severe course. The diagnosis of COVID-19 was established based on the detection of SARS-CoV-2 RNA by PCR in swabs taken from the nasopharynx and oropharynx. Serum levels of cytokines (IL-1β, IL-4, IL-6, IFNα, and IFNγ) were measured by IFA using kits from Vector Best OJSC (Novosibirsk, Russia). Results: showed that the levels of anti-inflammatory cytokines (IL-1β and IL-6) and anti- inflammatory (IL-4) cytokines are dramatically increased in patients with ENT diseases against the background of COVID-19. Also, high levels are more common in severe COVID-19. Interferons in COVID-19 have multidirectional synthesis: IFNα decreases and IFNγ increases. Conclusions. The state of immunodeficiency of COVID-19, which develops due to lymphopenia in patients with ENT diseases, is the main pathogenetic mechanism of the "cytokine storm" syndrome when the synthesis of pro-inflammatory (IL-1β and IL-6) is increased. and pro-inflammatory (IL-4) cytokines. In addition, the maximum value of these cytokines was recorded in patients with severe COVID-19. The synthesis of type I and II interferons against the background of COVID-19 in patients with ENT diseases changed depending on the severity of the disease. In moderately severe patients, the level of IFNα decreased by 1.4 times, and in severe patients by 1.9 times. However, the level of IFNg was 2 times higher in moderate patients than in controls, and 2.3 times higher in severe patients.

Maqola ma’lumotlari
MualliflarAMONOV Erkin Inoyatovich, MUSAKHODJAEVA Diloram Abdullaevna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2023-08-18
Jild8
Son3
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

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пациенты с ЛОР-заболеваниями, COVID-19, цитокины, Patients with ENT diseases, COVID-19, cytokines, LOR kasalliklari bilan og'rigan bemorlar, COVID-19, sitokinlar

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APAAMONOV Erkin Inoyatovich, & MUSAKHODJAEVA Diloram Abdullaevna (2023). THE ROLE OF PRO-INFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES DURING COVID-19 IN PATIENTS WITH CHRONIC ENT DISEASE. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 8(3). https://tadqiqot.uz/index.php/biomedicine/article/view/7745
GOST (OAK)AMONOV Erkin Inoyatovich, MUSAKHODJAEVA Diloram Abdullaevna THE ROLE OF PRO-INFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES DURING COVID-19 IN PATIENTS WITH CHRONIC ENT DISEASE // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2023. – T. 8, № 3.
MLAAMONOV Erkin Inoyatovich, and MUSAKHODJAEVA Diloram Abdullaevna. “THE ROLE OF PRO-INFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES DURING COVID-19 IN PATIENTS WITH CHRONIC ENT DISEASE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 8(3), 2023. https://tadqiqot.uz/index.php/biomedicine/article/view/7745
ChicagoAMONOV Erkin Inoyatovich, and MUSAKHODJAEVA Diloram Abdullaevna. “THE ROLE OF PRO-INFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES DURING COVID-19 IN PATIENTS WITH CHRONIC ENT DISEASE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 8(3) (2023). https://tadqiqot.uz/index.php/biomedicine/article/view/7745
HarvardAMONOV Erkin Inoyatovich, and MUSAKHODJAEVA Diloram Abdullaevna (2023) ‘THE ROLE OF PRO-INFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES DURING COVID-19 IN PATIENTS WITH CHRONIC ENT DISEASE’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 8(3). https://tadqiqot.uz/index.php/biomedicine/article/view/7745
BibTeX
@article{amonoverkininoyatovich2023,
  title = {THE ROLE OF PRO-INFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES DURING COVID-19 IN PATIENTS WITH CHRONIC ENT DISEASE},
  author = {AMONOV Erkin Inoyatovich and MUSAKHODJAEVA Diloram Abdullaevna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2023},
  volume = {8},
  number = {3},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/7745}
}

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