Morphometric and ploidometric studies of breast cancer and their prognostic significance

ALIMKHODZHAEVA Lola Telmanovna, BOZOROVA Lutfiya Makhmudovna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2023-yil

Annotatsiya

This article describes the indicators of DNA content in the nuclei of cell suspensions during flow cytophotometry, which differ significantly from the results of photometry of histological and cytological preparations stained according to Feulgen. With flow photometry, the amount of DNA is measured not only in the nuclei of epithelial cells in neoplasia, but also in the nuclei of cells in the stroma, blood vessels, and other structures. These conditions of flow photometry significantly change the nature of the histograms of the distribution of nuclei, as a rule, towards the predominance of the diploid peak due to the nuclei of non-tumor cells. If monoclonal antibody "tags" are used in flow cytometry to detect the cell population of interest, then in this case the result of the study may also be unreliable, since monoclonal antibodies can be expressed both in carcinomas and in benign tumors and normal breast tissue. When diagnosing the last stage, the degree of differentiation of carcinoma is determined by ploidy values. The ploidy of cell nuclei 4.5-5.4s indicates the first, highly differentiated degree, 5.5-6.4s the second, moderately differentiated degree, 6.5-7.4s - the third, low-differentiated. Thus, this research method makes it possible to clarify the diagnosis of the stages of carcinogenesis in the mammary gland and make informed decisions regarding benign processes, borderline conditions, and malignant neoplasms. The data obtained can be used as additional differential diagnostic criteria for morphological diagnosis of the stages of carcinogenesis in the mammary gland.

Maqola ma’lumotlari
MualliflarALIMKHODZHAEVA Lola Telmanovna, BOZOROVA Lutfiya Makhmudovna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2023-02-07
Jild7
Son6
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

Рак молочной железы, канцерогенез, диагностика, факторы прогноза, Breast cancer, carcinogenesis, diagnosis, prognostic factors, Sut bezi saratoni, kanserogenez, diagnostika, prognostik omillar

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAALIMKHODZHAEVA Lola Telmanovna, & BOZOROVA Lutfiya Makhmudovna (2023). MORPHOMETRIC AND PLOIDOMETRIC STUDIES OF BREAST CANCER AND THEIR PROGNOSTIC SIGNIFICANCE. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(6). https://tadqiqot.uz/index.php/biomedicine/article/view/6748
GOST (OAK)ALIMKHODZHAEVA Lola Telmanovna, BOZOROVA Lutfiya Makhmudovna MORPHOMETRIC AND PLOIDOMETRIC STUDIES OF BREAST CANCER AND THEIR PROGNOSTIC SIGNIFICANCE // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2023. – T. 7, № 6.
MLAALIMKHODZHAEVA Lola Telmanovna, and BOZOROVA Lutfiya Makhmudovna. “MORPHOMETRIC AND PLOIDOMETRIC STUDIES OF BREAST CANCER AND THEIR PROGNOSTIC SIGNIFICANCE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(6), 2023. https://tadqiqot.uz/index.php/biomedicine/article/view/6748
ChicagoALIMKHODZHAEVA Lola Telmanovna, and BOZOROVA Lutfiya Makhmudovna. “MORPHOMETRIC AND PLOIDOMETRIC STUDIES OF BREAST CANCER AND THEIR PROGNOSTIC SIGNIFICANCE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(6) (2023). https://tadqiqot.uz/index.php/biomedicine/article/view/6748
HarvardALIMKHODZHAEVA Lola Telmanovna, and BOZOROVA Lutfiya Makhmudovna (2023) ‘MORPHOMETRIC AND PLOIDOMETRIC STUDIES OF BREAST CANCER AND THEIR PROGNOSTIC SIGNIFICANCE’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(6). https://tadqiqot.uz/index.php/biomedicine/article/view/6748
BibTeX
@article{alimkhodzhaevalolatelmanovna2023,
  title = {MORPHOMETRIC AND PLOIDOMETRIC STUDIES OF BREAST CANCER AND THEIR PROGNOSTIC SIGNIFICANCE},
  author = {ALIMKHODZHAEVA Lola Telmanovna and BOZOROVA Lutfiya Makhmudovna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2023},
  volume = {7},
  number = {6},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/6748}
}

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