Objective: To study the distribution of allele and genotype frequencies of the polymorphic region G197A (rs2275913) of the IL-17A gene and A6986G (rs776746) of the CYP3A5 gene in patients with Graves' disease and establish the contribution to the development of the disease.Methods: The main group consisted of 97 patients with Graves' disease. The surveyed group consisted of individuals observed at the Department of Endocrinology of the Samarkand State Medical University. The study control group included 66 donors without thyroid pathology.Results: In this study, we studied the distribution of allele and genotype frequencies of the polymorphic variant G-197A (rs2275913) of the IL-17A gene in patients with DTG. As can be seen from our results, the risk marker for the development of DTG is the A allele and the homozygous AA genotype (12.37% and 3.03%, respectively; OR = 4.518; 95% CI: 0.977 > 4.518 > 20.899; χ2 = 4.365 (p =0.03669)).Conclusions. Thus, a significant increase in the A197 allele confirms the involvement of systemic inflammatory reactions in the pathogenesis of such a disease as diffuse toxic goiter.
| Mualliflar | Qodirov Avaz Eshmamatovich, Ziyadullaev Shukhrat Xudoyberdievich, Kim Antonina Amurovna, Kamalov Zaynitdin Sayfutdinovich, Ruzibakieva Malika Ruslanovna, Olimjonova Farangiz Jasur qizi |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2022-10-04 |
| Jild | 7 |
| Son | 4 |
| Til | Rus |
Диффузный токсический зоб, полиморфизм, иммунной системы, ген, Diffuse toxic goiter, polymorphism, immune system, Diffuz toksik buqoq, polimorfizm, immune tizim, gen
Purpose of the study. To study the effect of cervicitis on pregnancy to prevent complications of childbirth and the postpartum period in women. Materials and research methods. In the clinic of Samara State Medical…
Aim: The purpose of the study was to evaluate some external factors predisposing to the development of iron deficiency anemia associated with Helicobacter pylori. Material and methods of the study: The study was…
Objective: To assess the nature and significance of changes in parameters characterizing the functional state of external respiration during the perioperative period in parturient women with various degrees of obesity…
Objective: This study evaluates the main methods of treatment of patients with deep burns, as well as patients with thermal trauma complicated by thermal trauma, compared with patients with early surgical treatment…
The purpose of the study: to study the incidence and quality of life in patients with urinary incontinence and / or urinary incontinence who applied to the clinic of Samara State Medical University No. 1. Materials and…
The results of surgical treatment of patients with liver echinococcosis by various methods of antiparasitic treatment of the residual cavity have been analyzed. The obtained research data made it possible to conclude…
The purpose of the study: to improve the methods of treatment of hyperplastic processes of the endometrium. Materials and methods: the object of the study were 40 women with hyperplastic processes and 20 control group…
Objective: The authors examined 1033 patients with acute calculous cholecystitis (OCC) on the background of obesity. Methods: In the main group (2021) -579 (56.1%) patients, the therapeutic and diagnostic algorithm was…
Purpose of the study. To study reproductive and perinatal risks in women with AIT, to develop effective methods for preventing complications. Materials and research methods. In the clinic of SamSMU No. 1, after…
Objective:The authors found a significant increase in the total coagulating activity of blood, an increase in the concentration of fibrinogen and proconvertin, and an increase in the number of platelets in patients with…
Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar