The role of polymorphic variants of IL17A and cytochrome P450 genes with graves' disease

Qodirov Avaz Eshmamatovich, Ziyadullaev Shukhrat Xudoyberdievich, Kim Antonina Amurovna, Kamalov Zaynitdin Sayfutdinovich, Ruzibakieva Malika Ruslanovna, Olimjonova Farangiz Jasur qizi

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2022-yil

Annotatsiya

Objective: To study the distribution of allele and genotype frequencies of the polymorphic region G197A (rs2275913) of the IL-17A gene and A6986G (rs776746) of the CYP3A5 gene in patients with Graves' disease and establish the contribution to the development of the disease.Methods: The main group consisted of 97 patients with Graves' disease. The surveyed group consisted of individuals observed at the Department of Endocrinology of the Samarkand State Medical University. The study control group included 66 donors without thyroid pathology.Results: In this study, we studied the distribution of allele and genotype frequencies of the polymorphic variant G-197A (rs2275913) of the IL-17A gene in patients with DTG. As can be seen from our results, the risk marker for the development of DTG is the A allele and the homozygous AA genotype (12.37% and 3.03%, respectively; OR = 4.518; 95% CI: 0.977 > 4.518 > 20.899; χ2 = 4.365 (p =0.03669)).Conclusions. Thus, a significant increase in the A197 allele confirms the involvement of systemic inflammatory reactions in the pathogenesis of such a disease as diffuse toxic goiter.

Maqola ma’lumotlari
MualliflarQodirov Avaz Eshmamatovich, Ziyadullaev Shukhrat Xudoyberdievich, Kim Antonina Amurovna, Kamalov Zaynitdin Sayfutdinovich, Ruzibakieva Malika Ruslanovna, Olimjonova Farangiz Jasur qizi
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2022-10-04
Jild7
Son4
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

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Диффузный токсический зоб, полиморфизм, иммунной системы, ген, Diffuse toxic goiter, polymorphism, immune system, Diffuz toksik buqoq, polimorfizm, immune tizim, gen

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APAQodirov Avaz Eshmamatovich, Ziyadullaev Shukhrat Xudoyberdievich, Kim Antonina Amurovna, Kamalov Zaynitdin Sayfutdinovich, Ruzibakieva Malika Ruslanovna, & Olimjonova Farangiz Jasur qizi (2022). THE ROLE OF POLYMORPHIC VARIANTS OF IL17A AND CYTOCHROME P450 GENES WITH GRAVES' DISEASE. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(4). https://tadqiqot.uz/index.php/biomedicine/article/view/5550
GOST (OAK)Qodirov Avaz Eshmamatovich va b. THE ROLE OF POLYMORPHIC VARIANTS OF IL17A AND CYTOCHROME P450 GENES WITH GRAVES' DISEASE // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2022. – T. 7, № 4.
MLAQodirov Avaz Eshmamatovich, Ziyadullaev Shukhrat Xudoyberdievich, Kim Antonina Amurovna, Kamalov Zaynitdin Sayfutdinovich, Ruzibakieva Malika Ruslanovna, and Olimjonova Farangiz Jasur qizi. “THE ROLE OF POLYMORPHIC VARIANTS OF IL17A AND CYTOCHROME P450 GENES WITH GRAVES' DISEASE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(4), 2022. https://tadqiqot.uz/index.php/biomedicine/article/view/5550
ChicagoQodirov Avaz Eshmamatovich, Ziyadullaev Shukhrat Xudoyberdievich, Kim Antonina Amurovna, Kamalov Zaynitdin Sayfutdinovich, Ruzibakieva Malika Ruslanovna, and Olimjonova Farangiz Jasur qizi. “THE ROLE OF POLYMORPHIC VARIANTS OF IL17A AND CYTOCHROME P450 GENES WITH GRAVES' DISEASE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(4) (2022). https://tadqiqot.uz/index.php/biomedicine/article/view/5550
HarvardQodirov Avaz Eshmamatovich, Ziyadullaev Shukhrat Xudoyberdievich, Kim Antonina Amurovna, Kamalov Zaynitdin Sayfutdinovich, Ruzibakieva Malika Ruslanovna, and Olimjonova Farangiz Jasur qizi (2022) ‘THE ROLE OF POLYMORPHIC VARIANTS OF IL17A AND CYTOCHROME P450 GENES WITH GRAVES' DISEASE’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(4). https://tadqiqot.uz/index.php/biomedicine/article/view/5550
BibTeX
@article{qodirovavazeshmamatovich2022,
  title = {THE ROLE OF POLYMORPHIC VARIANTS OF IL17A AND CYTOCHROME P450 GENES WITH GRAVES' DISEASE},
  author = {Qodirov Avaz Eshmamatovich and Ziyadullaev Shukhrat Xudoyberdievich and Kim Antonina Amurovna and Kamalov Zaynitdin Sayfutdinovich and Ruzibakieva Malika Ruslanovna and Olimjonova Farangiz Jasur qizi},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2022},
  volume = {7},
  number = {4},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/5550}
}

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