Geometric heart remodeling in patients with coronary artery disease, after revascularization

Alyavi Bakhromhon Aniskhonovich, Shavkat Kadirovich Muminov

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2021-yil

Annotatsiya

Purpose of the study: to study the effect of the combination of valsartan with sacubitril on myocardial remodeling in patients with coronary heart disease after revascularization. Material and research methods. The study included 320 patients with coronary artery disease who underwent coronary revascularization. On average, the concentration of creatinine was 90.08 ± 1.72 µmol / L. All patients were divided into 2 groups: patients who received valsartan (group B, 160 people), patients who received ARNI - a combination of valsartan and sacubitrile molecules (group C, 160 people). Also, all patients were divided into 2 subgroups depending on the degree of eGFR decrease by the 3rd month of observation: patients with a decrease in eGFR by the 3rd month of observation more than 20% (group 1 - 59 patients) and less than 20% (group 2 - 261 sick). In dynamics, three months later, at the end of the first and second years of follow-up after revascularization, all patients underwent an echocardiographic study (EchoCG). Research results. During the observation process, it was found that against the background of both therapy options, there was a positive dynamics of indicators characterizing myocardial remodeling. he relative dynamics of indicators between the treatment groups was comparable at all stages of observation. In the group of patients with a decrease in eGFR of more than 20% in the first 3 months against the background of standard therapy after revascularization, no significant dynamics of the geometric parameters of the heart was observed at all follow-up periods. In the group of patients who received standard therapy with the addition of sacubitrile, both in group 1 and in group 2, more favorable geometric parameters were achieved, demonstrating a decrease in the severity of pathological remodeling and the formation of CHF. Conclusion. The use of sacubitril in the treatment of patients with coronary artery disease contributes to a more pronounced positive remodeling of the heart chambers - a decrease in the size of the chambers and the LV sphericity index. The effect is more pronounced in patients with a tendency to rapidly develop CKD.

Maqola ma’lumotlari
MualliflarAlyavi Bakhromhon Aniskhonovich, Shavkat Kadirovich Muminov
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2021-02-26
Jild6
Son1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

ишемическая болезнь сердца, ревасляризация, эхокардиография, ремоделирование миокарда, сакубитрил, coronary heart disease, revascularization, echocardiography, myocardial remodeling, sacubitril, юрак ишемик касаллиги, реваскулаштириш, эхокардиография, миокардни ремоделлаштириши, сакубитрил

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAlyavi Bakhromhon Aniskhonovich, & Shavkat Kadirovich Muminov (2021). GEOMETRIC HEART REMODELING IN PATIENTS WITH CORONARY ARTERY DISEASE, AFTER REVASCULARIZATION. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 6(1). https://tadqiqot.uz/index.php/biomedicine/article/view/211
GOST (OAK)Alyavi Bakhromhon Aniskhonovich, Shavkat Kadirovich Muminov GEOMETRIC HEART REMODELING IN PATIENTS WITH CORONARY ARTERY DISEASE, AFTER REVASCULARIZATION // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2021. – T. 6, № 1.
MLAAlyavi Bakhromhon Aniskhonovich, and Shavkat Kadirovich Muminov. “GEOMETRIC HEART REMODELING IN PATIENTS WITH CORONARY ARTERY DISEASE, AFTER REVASCULARIZATION.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 6(1), 2021. https://tadqiqot.uz/index.php/biomedicine/article/view/211
ChicagoAlyavi Bakhromhon Aniskhonovich, and Shavkat Kadirovich Muminov. “GEOMETRIC HEART REMODELING IN PATIENTS WITH CORONARY ARTERY DISEASE, AFTER REVASCULARIZATION.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 6(1) (2021). https://tadqiqot.uz/index.php/biomedicine/article/view/211
HarvardAlyavi Bakhromhon Aniskhonovich, and Shavkat Kadirovich Muminov (2021) ‘GEOMETRIC HEART REMODELING IN PATIENTS WITH CORONARY ARTERY DISEASE, AFTER REVASCULARIZATION’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 6(1). https://tadqiqot.uz/index.php/biomedicine/article/view/211
BibTeX
@article{alyavibakhromhonaniskhonovich2021,
  title = {GEOMETRIC HEART REMODELING IN PATIENTS WITH CORONARY ARTERY DISEASE, AFTER REVASCULARIZATION},
  author = {Alyavi Bakhromhon Aniskhonovich and Shavkat Kadirovich Muminov},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2021},
  volume = {6},
  number = {1},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/211}
}

Boshqa maqola uchun iqtibos tayyorlash

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali jurnalidan boshqa maqolalar

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar · 2021-yil arxivi

Tibbiyot sohasidagi boshqa maqolalar

Tibbiyot sohasidagi OAK jurnallari