Associations of fto (RS9939609) and pparg 2 (RS18012820) gene polymorphism in children with abdominal obesity and metabolic syndrome

Rustamov , Mardonkul, Garifulina , Lilya, Рустамов , Мардонкул, Гарифулина , Лиля, Rustamov , Mardonkul, Garifulina , Lilya

Халқаро илмий педиатрия журнали · 2024-yil

Annotatsiya

The original article presents the results of a study of the distribution frequency of the FTO (rs9939609) and PPARG 2 (rs18012820) gene polymorphisms in children with abdominal obesity and manifestations of metabolic syndrome, as well as children with normal body weight. The results of the study are recommended for widespread use in the practice of family doctors, pediatricians and pediatric endocrinologists. Objective of the study: to study the features of the association of the FTO (rs9939609) and PPARG 2 (RS18012820) gene polymorphism in children with abdominal obesity and manifestations of MS Materials and methods. 72 children with abdominal obesity and manifestations of metabolic syndrome and 40 children with normal body weight were examined. A comprehensive anthropometric, anamnestic, clinical, biochemical and molecular genetic study was conducted to determine the distribution frequency of the FTO gene polymorphism (rs9939609) and PPARG 2 (rs18012820). Statistical processing of the obtained data was performed on a personal computer using the Statistica 10 program. In genetic studies, allele frequencies and allele combination frequencies were calculated and their compliance with the Hardy-Weinberg equilibrium using the c2 criterion with the calculated ones, rejecting the null hypothesis at P < 0.05. Results. The results showed that the homozygous genotype of the FTO gene - T/T was found with a lower frequency in children with abdominal obesity and children with metabolic syndrome (c2=4,530, p=0,034), and the homozygous genotype A/A of the FTO gene was significantly more common in children with metabolic syndrome. In children with abdominal obesity, the Pro allele and Pro12Pro genotype were more common (85.5% and 73.6%) compared to children in the control group (76.2% and 60.0%). It was found that the Pro12Pro genotype of the PPARG-2 gene was statistically more common in children with MS - 84.6% compared to children who did not have this syndrome - 62.5% (c2=5,304, p=0,022). Conclusion. The genotype A/A and allele A of the FTO gene (rs9939609) have a predisposing value to the abdominal type of obesity and metabolic syndrome. The predominant genotype in children with the abdominal type of obesity and manifestations of metabolic syndrome was Pro12 Pro, and in children with the abdominal type of obesity without metabolic disorders, the frequency of the minor allele 12Ala was statistically higher compared to children with manifestations of metabolic syndrome, which allows us to classify this allele as protective for the development of metabolic disorders

Maqola ma’lumotlari
MualliflarRustamov , Mardonkul, Garifulina , Lilya, Рустамов , Мардонкул, Гарифулина , Лиля, Rustamov , Mardonkul, Garifulina , Lilya
JurnalХалқаро илмий педиатрия журнали
NashriyotАндижон давлат тиббиёт институти; In Science МЧЖ
ISSN2181-2926, 2181-2926
Nashr sanasi2024-07-30
Jild3
Son7
Betlar662-668
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-2926-2024-3-7-662-668
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-2926-2024-3-7-662-668 · Maqolaning asl sahifasi

Kalit so‘zlar

дети, абдоминальное ожирение, метаболический синдром, гена FTO, ген PPARG 2, children, abdominal obesity, metabolic syndrome, FTO gene, PPARG 2 gene, bolalar, abdominal semizlik, metobolik sindrom, gen FTO, gen PPARG

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APARustamov , Mardonkul, Garifulina , Lilya, Рустамов , Мардонкул, Гарифулина , Лиля, Rustamov , Mardonkul, & Garifulina , Lilya (2024). ASSOCIATIONS OF FTO (RS9939609) AND PPARG 2 (RS18012820) GENE POLYMORPHISM IN CHILDREN WITH ABDOMINAL OBESITY AND METABOLIC SYNDROME. Халқаро илмий педиатрия журнали, 3(7), 662-668. https://doi.org/10.56121/2181-2926-2024-3-7-662-668
GOST (OAK)Rustamov , Mardonkul va b. ASSOCIATIONS OF FTO (RS9939609) AND PPARG 2 (RS18012820) GENE POLYMORPHISM IN CHILDREN WITH ABDOMINAL OBESITY AND METABOLIC SYNDROME // Халқаро илмий педиатрия журнали. – 2024. – T. 3, № 7. – P. 662-668. – DOI: 10.56121/2181-2926-2024-3-7-662-668.
MLARustamov , Mardonkul, Garifulina , Lilya, Рустамов , Мардонкул, Гарифулина , Лиля, Rustamov , Mardonkul, and Garifulina , Lilya. “ASSOCIATIONS OF FTO (RS9939609) AND PPARG 2 (RS18012820) GENE POLYMORPHISM IN CHILDREN WITH ABDOMINAL OBESITY AND METABOLIC SYNDROME.” Халқаро илмий педиатрия журнали, 3(7), 662-668, 2024. https://doi.org/10.56121/2181-2926-2024-3-7-662-668
ChicagoRustamov , Mardonkul, Garifulina , Lilya, Рустамов , Мардонкул, Гарифулина , Лиля, Rustamov , Mardonkul, and Garifulina , Lilya. “ASSOCIATIONS OF FTO (RS9939609) AND PPARG 2 (RS18012820) GENE POLYMORPHISM IN CHILDREN WITH ABDOMINAL OBESITY AND METABOLIC SYNDROME.” Халқаро илмий педиатрия журнали, 3(7), 662-668 (2024). https://doi.org/10.56121/2181-2926-2024-3-7-662-668
HarvardRustamov , Mardonkul, Garifulina , Lilya, Рустамов , Мардонкул, Гарифулина , Лиля, Rustamov , Mardonkul, and Garifulina , Lilya (2024) ‘ASSOCIATIONS OF FTO (RS9939609) AND PPARG 2 (RS18012820) GENE POLYMORPHISM IN CHILDREN WITH ABDOMINAL OBESITY AND METABOLIC SYNDROME’, Халқаро илмий педиатрия журнали, 3(7), 662-668. https://doi.org/10.56121/2181-2926-2024-3-7-662-668
BibTeX
@article{rustamovmardonkul2024,
  title = {ASSOCIATIONS OF FTO (RS9939609) AND PPARG 2 (RS18012820) GENE POLYMORPHISM IN CHILDREN WITH ABDOMINAL OBESITY AND METABOLIC SYNDROME},
  author = {Rustamov , Mardonkul and Garifulina , Lilya and Рустамов , Мардонкул and Гарифулина , Лиля and Rustamov , Mardonkul and Garifulina , Lilya},
  journal = {Халқаро илмий педиатрия журнали},
  year = {2024},
  volume = {3},
  number = {7},
  pages = {662-668},
  doi = {10.56121/2181-2926-2024-3-7-662-668},
  url = {https://doi.org/10.56121/2181-2926-2024-3-7-662-668}
}

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