High-performance liquid chromatography technology (HPLC is one of the most important analytical methods used to analyze drugs and determine their components with high accuracy. This research focuses on using HPLC to estimate the amount of paracetamol in pharmaceutical tablets, which is one of the common medications used as a pain reliever and fever reducer. Verifying the accuracy and reliability of this analytical method is crucial to ensuring the quality and safety of drug products. The methodology involved preparing samples by crushing the tablets and dissolving them in a suitable solvent to obtain a homogeneous solution. Analysis was performed using a Supelco C18 25)cm x 4.6mm column)Determine the appropriate mobile phase, flow rate, and wavelength used for detection (243 nm). Standard solutions and actual samples were injected into the HPLC machine, where compounds were separated and the peak area and retention time for each sample was recorded. The resulting data was used to create a calibration curve and determine the paracetamol concentration in the unknown samples. The results showed a linear relationship between paracetamol concentration and peak area, which reflects the accuracy and reliability of the methodology used. The retention time was constant at approximately 5.2 min, indicating stable device performance and consistency of analysis conditions. The amount of paracetamol in the pharmaceutical tablets was estimated with high accuracy, and the results were found to be within acceptable limits according to pharmaceutical standards. The research concluded that HPLC technology is an effective and accurate tool to estimate the amount of paracetamol in pharmaceutical tablets. These results strengthen confidence in using HPLC as a standard for ensuring the quality and safety of pharmaceutical products. The study recommends that this technology should be widely adopted in quality control laboratories to ensure that products comply with international health standards.
| Mualliflar | Ahmed, Mohaned Habeb |
|---|---|
| Jurnal | Innovative Multidisciplinary Journal of Applied Technology |
| Nashr sanasi | 2024-08-27 |
| Jild | 2 |
| Son | 7 |
| Betlar | 299-314 |
| Til | Ingliz |
High performance liquid chromatography, paracetamol, pharmaceutical quality, quality control, quantitative analysis
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