Tetrazole derivatives are a prime class of heterocycles, very important to medicinal chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide moieties but also to their metabolic stability and other beneficial physicochemical properties. Although more than 20 FDA-approved drugs contain 1H- or 2H-tetrazole substituents, their exact binding mode, structural biology, 3D conformations, and in general their chemical behavior is not fully understood. Importantly, multicomponent reaction (MCR) chemistry offers convergent access to multiple tetrazole scaffolds providing the three important elements of novelty, diversity, and complexity, yet MCR pathways to tetrazoles are far from completely explored. Here, we review the use of multicomponent reactions for the preparation of substituted tetrazole derivatives. We highlight specific applications and general trends holding therein and discuss synthetic approaches and their value by analyzing scope and limitations, and also enlighten their receptor binding mode. Finally.
| Mualliflar | Tawi, Azher Majeed Abd Al-Zhara, Mohammad, Haneen Ahmed jassim, debis, Maha Naama dakhil, Sahib, Ayat Arif Abdul Abbas, Mahdi, Zainab Mohammed Abod |
|---|---|
| Jurnal | Innovative Multidisciplinary Journal of Applied Technology |
| Nashriyot | ТДТУ Қўқон филиали |
| ISSN | 2995-486X, 2995-486x |
| Nashr sanasi | 2024-08-10 |
| Jild | 2 |
| Son | 7 |
| Betlar | 91-96 |
| Til | Ingliz |
| Indeksga qo‘shilgan | 2026-08-26 |
| APA | Tawi, Azher Majeed Abd Al-Zhara, Mohammad, Haneen Ahmed jassim, debis, Maha Naama dakhil, Sahib, Ayat Arif Abdul Abbas, & Mahdi, Zainab Mohammed Abod (2024). Tetrazole Anticancer and Antibodies. Innovative Multidisciplinary Journal of Applied Technology, 2(7), 91-96. https://www.multijournals.org/index.php/innovative/article/view/1945 |
|---|---|
| GOST (OAK) | Tawi, Azher Majeed Abd Al-Zhara va b. Tetrazole Anticancer and Antibodies // Innovative Multidisciplinary Journal of Applied Technology. – 2024. – T. 2, № 7. – P. 91-96. |
| MLA | Tawi, Azher Majeed Abd Al-Zhara, Mohammad, Haneen Ahmed jassim, debis, Maha Naama dakhil, Sahib, Ayat Arif Abdul Abbas, and Mahdi, Zainab Mohammed Abod. “Tetrazole Anticancer and Antibodies.” Innovative Multidisciplinary Journal of Applied Technology, 2(7), 91-96, 2024. https://www.multijournals.org/index.php/innovative/article/view/1945 |
| Chicago | Tawi, Azher Majeed Abd Al-Zhara, Mohammad, Haneen Ahmed jassim, debis, Maha Naama dakhil, Sahib, Ayat Arif Abdul Abbas, and Mahdi, Zainab Mohammed Abod. “Tetrazole Anticancer and Antibodies.” Innovative Multidisciplinary Journal of Applied Technology, 2(7), 91-96 (2024). https://www.multijournals.org/index.php/innovative/article/view/1945 |
| Harvard | Tawi, Azher Majeed Abd Al-Zhara, Mohammad, Haneen Ahmed jassim, debis, Maha Naama dakhil, Sahib, Ayat Arif Abdul Abbas, and Mahdi, Zainab Mohammed Abod (2024) ‘Tetrazole Anticancer and Antibodies’, Innovative Multidisciplinary Journal of Applied Technology, 2(7), 91-96. https://www.multijournals.org/index.php/innovative/article/view/1945 |
| BibTeX | @article{tawiazhermajeedabdalzhara2024,
title = {Tetrazole Anticancer and Antibodies},
author = {Tawi, Azher Majeed Abd Al-Zhara and Mohammad, Haneen Ahmed jassim and debis, Maha Naama dakhil and Sahib, Ayat Arif Abdul Abbas and Mahdi, Zainab Mohammed Abod},
journal = {Innovative Multidisciplinary Journal of Applied Technology},
year = {2024},
volume = {2},
number = {7},
pages = {91-96},
url = {https://www.multijournals.org/index.php/innovative/article/view/1945}
} |
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