Tetrazole derivatives are a prime class of heterocycles, very important to medicinal chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide moieties but also to their metabolic stability and other beneficial physicochemical properties. Although more than 20 FDA-approved drugs contain 1H- or 2H-tetrazole substituents, their exact binding mode, structural biology, 3D conformations, and in general their chemical behavior is not fully understood. Importantly, multicomponent reaction (MCR) chemistry offers convergent access to multiple tetrazole scaffolds providing the three important elements of novelty, diversity, and complexity, yet MCR pathways to tetrazoles are far from completely explored. Here, we review the use of multicomponent reactions for the preparation of substituted tetrazole derivatives. We highlight specific applications and general trends holding therein and discuss synthetic approaches and their value by analyzing scope and limitations, and also enlighten their receptor binding mode. Finally.
| Mualliflar | Tawi, Azher Majeed Abd Al-Zhara, Mohammad, Haneen Ahmed jassim, debis, Maha Naama dakhil, Sahib, Ayat Arif Abdul Abbas, Mahdi, Zainab Mohammed Abod |
|---|---|
| Jurnal | Innovative Multidisciplinary Journal of Applied Technology |
| Nashr sanasi | 2024-08-10 |
| Jild | 2 |
| Son | 7 |
| Betlar | 91-96 |
| Til | Ingliz |
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