Preoperative prediction of infectious-inflammatory complications after endoscopic ureterolithotripsy in adults: development and internal validation of a discriminant model

Khudaybergenov , Ulugbek, Abdukarimov , Olimjon, Isroilov , Bekzod, Rakhimboyev , Asqar

Жанубий оролбўйи тиббиёт журнали · 2026-yil

Annotatsiya

Infectious-inflammatory complications (IIC) remain among the most clinically significant adverse events after endoscopic treatment of ureteral stones and, in their severe forms, may progress to urosepsis; reliable preoperative risk stratification could allow prophylaxis and monitoring to be individualized. This study aimed to identify independent predictors of IIC in adults after endoscopic ureterolithotripsy and to develop and internally validate a discriminant prognostic model. We analyzed 385 adult patients who underwent endoscopic treatment of ureteral stones at a single tertiary urology center; demographic, laboratory, stone-related, and operative variables were compared between patients with and without IIC using univariate tests, independent predictors were selected by stepwise discriminant analysis, and the resulting canonical discriminant function was internally validated on an independent prospectively assembled sample of 43 patients. IIC occurred in 76 of 385 patients (19.7%) and were predominantly mild: postoperative fever without an infectious focus (50.0%) and urinary tract infection (28.9%) prevailed, whereas acute pyelonephritis (18.4%) and urosepsis (2.6%) were uncommon; female sex (p = 0.031), preoperative bacteriuria and pyuria, combined bacteriuria plus pyuria, preoperative upper-tract drainage, longer operative time, and greater blood loss were significantly associated with IIC, whereas age, body-mass index, and stone location, size, and density were not. The final four-variable model — pyuria, peripheral-blood leukocyte count, bacteriuria, and emergency upper-tract drainage — showed strong discrimination (eigenvalue 0.754; canonical correlation 0.656; Wilks' λ = 0.570; χ² = 214.1; p < 0.000001), with sensitivity 76.3%, specificity 81.5%, and overall accuracy 80.4%; on internal validation, overall accuracy was 81.4%, sensitivity 81.8%, and specificity 81.3%. A simple four-predictor discriminant model built from routinely available preoperative parameters thus reliably stratifies adults by the risk of IIC after endoscopic ureterolithotripsy, and its high negative predictive value identifies low-risk patients and supports individualized antimicrobial prophylaxis and postoperative monitoring.

Maqola ma’lumotlari
MualliflarKhudaybergenov , Ulugbek, Abdukarimov , Olimjon, Isroilov , Bekzod, Rakhimboyev , Asqar
JurnalЖанубий оролбўйи тиббиёт журнали
NashriyotТТА Урганч филиали
ISSN3093-8740, 2012-2021
Nashr sanasi2026-09-28
Jild2
Son5/2
Betlar42-51
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-09-30

Maqolaning asl sahifasi

Kalit so‘zlar

ureteral calculi, ureteroscopy, postoperative complications, urinary tract infection, urosepsis

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKhudaybergenov , Ulugbek, Abdukarimov , Olimjon, Isroilov , Bekzod, & Rakhimboyev , Asqar (2026). Preoperative prediction of infectious-inflammatory complications after endoscopic ureterolithotripsy in adults: development and internal validation of a discriminant model. Жанубий оролбўйи тиббиёт журнали, 2(5/2), 42-51. http://journal.urdti.uz/index/article/view/1081
GOST (OAK)Khudaybergenov , Ulugbek va b. Preoperative prediction of infectious-inflammatory complications after endoscopic ureterolithotripsy in adults: development and internal validation of a discriminant model // Жанубий оролбўйи тиббиёт журнали. – 2026. – T. 2, № 5/2. – P. 42-51.
MLAKhudaybergenov , Ulugbek, Abdukarimov , Olimjon, Isroilov , Bekzod, and Rakhimboyev , Asqar. “Preoperative prediction of infectious-inflammatory complications after endoscopic ureterolithotripsy in adults: development and internal validation of a discriminant model.” Жанубий оролбўйи тиббиёт журнали, 2(5/2), 42-51, 2026. http://journal.urdti.uz/index/article/view/1081
ChicagoKhudaybergenov , Ulugbek, Abdukarimov , Olimjon, Isroilov , Bekzod, and Rakhimboyev , Asqar. “Preoperative prediction of infectious-inflammatory complications after endoscopic ureterolithotripsy in adults: development and internal validation of a discriminant model.” Жанубий оролбўйи тиббиёт журнали, 2(5/2), 42-51 (2026). http://journal.urdti.uz/index/article/view/1081
HarvardKhudaybergenov , Ulugbek, Abdukarimov , Olimjon, Isroilov , Bekzod, and Rakhimboyev , Asqar (2026) ‘Preoperative prediction of infectious-inflammatory complications after endoscopic ureterolithotripsy in adults: development and internal validation of a discriminant model’, Жанубий оролбўйи тиббиёт журнали, 2(5/2), 42-51. http://journal.urdti.uz/index/article/view/1081
BibTeX
@article{khudaybergenovulugbek2026,
  title = {Preoperative prediction of infectious-inflammatory complications after endoscopic ureterolithotripsy in adults: development and internal validation of a discriminant model},
  author = {Khudaybergenov , Ulugbek and Abdukarimov , Olimjon and Isroilov , Bekzod and Rakhimboyev , Asqar},
  journal = {Жанубий оролбўйи тиббиёт журнали},
  year = {2026},
  volume = {2},
  number = {5/2},
  pages = {42-51},
  url = {http://journal.urdti.uz/index/article/view/1081}
}

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