Synthesis, spectroscopic and molecular docking studies of a copper(ii) complex with 2- AMINO-5-ALLYLTHIO-1,3,4-THIADIAZOLE

UZAKBERGENOVA, Gulmira, ATASHOV, Aziz, UZAKBERGENOVA, Zamira, TORAMBETOV, Batirbay, KALILAYEVA, Albina, KADIROVA, Shahnoza

Ўзбекистон Миллий университети хабарлари · 2026-yil

Annotatsiya

In this study, new copper (II) complexes based on the ligand 2-amino-5-allylthio-1,3,4-thiadiazole (L) were synthesized, and theirstructures were characterized using elemental analysis, IR spectroscopy, and thermal analysis (TG/DTA). Spectroscopic analysesrevealed that the [Cu(L)4Cl]Cl complex exhibits a tetragonal pyramidal geometry with monodentately coordinated ligands. Thermalanalysis confirmed the stability of the complex up to 180°C, with CuO forming as the final decomposition product. Moleculardocking studies demonstrated the high affinity of these complexes for human breast cancer (MCF-7 cell line) receptors, namelyERα, HER2, and EGFR. Notably, the complex exhibited the highest binding energy with the ERα receptor (–7.40 kcal/mol),highlighting its potential as an anti-cancer agent

Maqola ma’lumotlari
MualliflarUZAKBERGENOVA, Gulmira, ATASHOV, Aziz, UZAKBERGENOVA, Zamira, TORAMBETOV, Batirbay, KALILAYEVA, Albina, KADIROVA, Shahnoza
JurnalЎзбекистон Миллий университети хабарлари
NashriyotЎзбекистон Миллий университети
ISSN2181-7324, 3093-8996
Nashr sanasi2026-09-24
Jild3
Son3.3
Betlar375-378
TilIngliz
Ilmiy sohaKimyo
Indeksga qo‘shilgan2026-09-25

Maqolaning asl sahifasi

Kalit so‘zlar

2-amino-5-alliltio-1,3,4-thiadiazole, copper complexes, molecular docking, MCF-7 cell line, thermal analysis, ERα receptor, IR spectroscopy., 2-амино-5-аллилтио-1,3,4-тиадиазол, комплексы меди, молекулярный докинг, клеточная линия MCF- 7, термический анализ, рецептор ERα, ИК-спектроскопия., 2-amino-5-alliltio-1,3,4-tiadiazol, mis komplekslari, molekulyar doking, MCF-7 hujayra liniyasi, termik tahlil, ERα retseptori, IQ-spektroskopiya.

Ilmiy soha

Kimyo

Iqtibos keltirish

APAUZAKBERGENOVA, Gulmira, ATASHOV, Aziz, UZAKBERGENOVA, Zamira, TORAMBETOV, Batirbay, KALILAYEVA, Albina, & KADIROVA, Shahnoza (2026). SYNTHESIS, SPECTROSCOPIC AND MOLECULAR DOCKING STUDIES OF A COPPER(II) COMPLEX WITH 2- AMINO-5-ALLYLTHIO-1,3,4-THIADIAZOLE. Ўзбекистон Миллий университети хабарлари, 3(3.3), 375-378. https://journals.nuu.uz/index.php/actanuuz/article/view/15070
GOST (OAK)UZAKBERGENOVA, Gulmira va b. SYNTHESIS, SPECTROSCOPIC AND MOLECULAR DOCKING STUDIES OF A COPPER(II) COMPLEX WITH 2- AMINO-5-ALLYLTHIO-1,3,4-THIADIAZOLE // Ўзбекистон Миллий университети хабарлари. – 2026. – T. 3, № 3.3. – P. 375-378.
MLAUZAKBERGENOVA, Gulmira, ATASHOV, Aziz, UZAKBERGENOVA, Zamira, TORAMBETOV, Batirbay, KALILAYEVA, Albina, and KADIROVA, Shahnoza. “SYNTHESIS, SPECTROSCOPIC AND MOLECULAR DOCKING STUDIES OF A COPPER(II) COMPLEX WITH 2- AMINO-5-ALLYLTHIO-1,3,4-THIADIAZOLE.” Ўзбекистон Миллий университети хабарлари, 3(3.3), 375-378, 2026. https://journals.nuu.uz/index.php/actanuuz/article/view/15070
ChicagoUZAKBERGENOVA, Gulmira, ATASHOV, Aziz, UZAKBERGENOVA, Zamira, TORAMBETOV, Batirbay, KALILAYEVA, Albina, and KADIROVA, Shahnoza. “SYNTHESIS, SPECTROSCOPIC AND MOLECULAR DOCKING STUDIES OF A COPPER(II) COMPLEX WITH 2- AMINO-5-ALLYLTHIO-1,3,4-THIADIAZOLE.” Ўзбекистон Миллий университети хабарлари, 3(3.3), 375-378 (2026). https://journals.nuu.uz/index.php/actanuuz/article/view/15070
HarvardUZAKBERGENOVA, Gulmira, ATASHOV, Aziz, UZAKBERGENOVA, Zamira, TORAMBETOV, Batirbay, KALILAYEVA, Albina, and KADIROVA, Shahnoza (2026) ‘SYNTHESIS, SPECTROSCOPIC AND MOLECULAR DOCKING STUDIES OF A COPPER(II) COMPLEX WITH 2- AMINO-5-ALLYLTHIO-1,3,4-THIADIAZOLE’, Ўзбекистон Миллий университети хабарлари, 3(3.3), 375-378. https://journals.nuu.uz/index.php/actanuuz/article/view/15070
BibTeX
@article{uzakbergenovagulmira2026,
  title = {SYNTHESIS, SPECTROSCOPIC AND MOLECULAR DOCKING STUDIES OF A COPPER(II) COMPLEX WITH 2- AMINO-5-ALLYLTHIO-1,3,4-THIADIAZOLE},
  author = {UZAKBERGENOVA, Gulmira and ATASHOV, Aziz and UZAKBERGENOVA, Zamira and TORAMBETOV, Batirbay and KALILAYEVA, Albina and KADIROVA, Shahnoza},
  journal = {Ўзбекистон Миллий университети хабарлари},
  year = {2026},
  volume = {3},
  number = {3.3},
  pages = {375-378},
  url = {https://journals.nuu.uz/index.php/actanuuz/article/view/15070}
}

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