In vivo investigation of the effects of the C-4 composition on the functional state of the central and peripheral nervous systems

MAHMUDOV, Lazizbek, YAKUBOVA, Rana, TAGAYALIEVA, Nigora

Ўзбекистон Миллий университети хабарлари · 2026-yil

Annotatsiya

In the development of pharmacological agents and their introduction into clinical practice, it is essential to comprehensivelyevaluate not only their primary therapeutic activity but also their effects on the vital systems of the body, including the centralnervous system. In the present experimental study, the effects of the C-4 composition on the functional state of the central nervoussystem were investigated at a therapeutic dose of 10 mg/kg and at a dose of 20 mg/kg, which was twice the therapeutic dose. Theobtained results showed that the combined administration of the C-4 composition with sedative agents did not cause pronouncedadverse effects. At the same time, the composition was found to exhibit antagonistic properties against the pharmacological effectsof certain hypnotic agents, particularly chloral hydrate. These findings are of considerable scientific and practical importance forevaluating the effects of the C-4 composition on the central nervous system and determining its safety profile.

Maqola ma’lumotlari
MualliflarMAHMUDOV, Lazizbek, YAKUBOVA, Rana, TAGAYALIEVA, Nigora
JurnalЎзбекистон Миллий университети хабарлари
NashriyotЎзбекистон Миллий университети
ISSN2181-7324, 3093-8996
Nashr sanasi2026-09-17
Jild3
Son3.3
Betlar58-61
TilIngliz
Indeksga qo‘shilgan2026-09-18

Maqolaning asl sahifasi

Kalit so‘zlar

central and peripheral nervous systems; C-4 composition; in vivo study; dose-dependent effects; glycyrrhizinate, L- carnitine, quercetin, and cysteine; latency period; sleep duration; number of animals that fell asleep., центральная и периферическая нервная система; композиция C-4; исследование in vivo; дозозависимые эффекты; глицирризинат, L-карнитин, кверцетин и цистеин; латентный период; продолжительность сна; количество уснувших животных., markaziy va periferik nerv sistemasi, C-4 kompozitsiyasi; in vivo tadqiqot; dozaga bog‘liq ta’sirlar; glitsirrizinat, L- karnitin, kversetin va sistein; latent davr, uyqu davomiyligi va uyquga ketgan hayvonlar soni baholash.

Iqtibos keltirish

APAMAHMUDOV, Lazizbek, YAKUBOVA, Rana, & TAGAYALIEVA, Nigora (2026). IN VIVO INVESTIGATION OF THE EFFECTS OF THE C-4 COMPOSITION ON THE FUNCTIONAL STATE OF THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS. Ўзбекистон Миллий университети хабарлари, 3(3.3), 58-61. https://journals.nuu.uz/index.php/actanuuz/article/view/14946
GOST (OAK)MAHMUDOV, Lazizbek, YAKUBOVA, Rana, TAGAYALIEVA, Nigora IN VIVO INVESTIGATION OF THE EFFECTS OF THE C-4 COMPOSITION ON THE FUNCTIONAL STATE OF THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS // Ўзбекистон Миллий университети хабарлари. – 2026. – T. 3, № 3.3. – P. 58-61.
MLAMAHMUDOV, Lazizbek, YAKUBOVA, Rana, and TAGAYALIEVA, Nigora. “IN VIVO INVESTIGATION OF THE EFFECTS OF THE C-4 COMPOSITION ON THE FUNCTIONAL STATE OF THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS.” Ўзбекистон Миллий университети хабарлари, 3(3.3), 58-61, 2026. https://journals.nuu.uz/index.php/actanuuz/article/view/14946
ChicagoMAHMUDOV, Lazizbek, YAKUBOVA, Rana, and TAGAYALIEVA, Nigora. “IN VIVO INVESTIGATION OF THE EFFECTS OF THE C-4 COMPOSITION ON THE FUNCTIONAL STATE OF THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS.” Ўзбекистон Миллий университети хабарлари, 3(3.3), 58-61 (2026). https://journals.nuu.uz/index.php/actanuuz/article/view/14946
HarvardMAHMUDOV, Lazizbek, YAKUBOVA, Rana, and TAGAYALIEVA, Nigora (2026) ‘IN VIVO INVESTIGATION OF THE EFFECTS OF THE C-4 COMPOSITION ON THE FUNCTIONAL STATE OF THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS’, Ўзбекистон Миллий университети хабарлари, 3(3.3), 58-61. https://journals.nuu.uz/index.php/actanuuz/article/view/14946
BibTeX
@article{mahmudovlazizbek2026,
  title = {IN VIVO INVESTIGATION OF THE EFFECTS OF THE C-4 COMPOSITION ON THE FUNCTIONAL STATE OF THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS},
  author = {MAHMUDOV, Lazizbek and YAKUBOVA, Rana and TAGAYALIEVA, Nigora},
  journal = {Ўзбекистон Миллий университети хабарлари},
  year = {2026},
  volume = {3},
  number = {3.3},
  pages = {58-61},
  url = {https://journals.nuu.uz/index.php/actanuuz/article/view/14946}
}

Boshqa maqola uchun iqtibos tayyorlash

Ўзбекистон Миллий университети хабарлари jurnalidan boshqa maqolalar

Ўзбекистон Миллий университети хабарлари — barcha maqolalar · 2026-yil arxivi

MAHMUDOV, Lazizbek — boshqa maqolalari