The aim of this study was to analyze the characteristics of the formation and functioning of the reproductive system in girls with congenital adrenal cortex dysfunction based on clinical, hormonal, and instrumental examination methods. The study was conducted between 2020 and 2026 in medical institutions of the Samarkand region and included a retrospective and prospective analysis of 20 patients under dynamic observation. The assessment comprised age and socio-demographic characteristics, general somatic status, anthropometric parameters, gynecological status, features of menstrual function, as well as the results of laboratory investigations (17-hydroxyprogesterone, testosterone, DHEA-S, cortisol) and ultrasound examination of the reproductive organs. The results demonstrated that the majority of girls with congenital adrenal cortex dysfunction exhibited clinical signs of hyperandrogenism, including acne, seborrhea, male-pattern hair growth, clitoromegaly, and insufficient development of the mammary glands. Menstrual cycle disorders were common, with opsomenorrhea and oligomenorrhea predominating, while amenorrhea and algodysmenorrhea were observed less frequently. Ultrasound findings revealed reduced uterine and ovarian sizes compared with age norms, and in some cases, polycystic ovarian changes. These findings confirm the significant negative impact of congenital adrenal cortex dysfunction on reproductive system development and emphasize the importance of early diagnosis and a comprehensive multidisciplinary approach to the management of affected patients
Аскарова Зебо Зафаржоновна, Абдурасулов Шохрух Улугбек ўғли · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2026-05-25
Шодикулова Гуландом Зикриевна, Юнусова Зарнигор · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2026-03-27
The aim of the study is to investigate the prevalence and incidence of connective tissue dysplasia among pregnant women in primary health care and to develop a system for managing patients. The study was conducted at…
Махмудова Севара Эркиновна · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2026-05-25
Негмаджанов Баходур Болтаевич, Валиев Шухрат Насимович, Эрназарова Мохинур Зайнабиддиновна · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2026-03-27
In recent years, the issue of the impact of environmental factors on human health has become one of the most pressing areas of research in medical and biological sciences. Pollution of the atmosphere, water, and soil…
Негмаджанов Баходур Болтаевич, Азимова Шахноза Талъатовна · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2026-05-25
Негмаджанов Бахадур Болтаевич, Зоирова Нилуфар Аслиддиновна, Шавкатов Хасан Шавкатович · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2026-03-27
This article is devoted to contemporary clinical approaches to the management of patients with benign tumors of the uterus and its adnexa in the setting of genital prolapse. The paper highlights etiological factors…
Облакулова Рухсора, Насирова Зебинисо Азизовна · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2026-05-25
Назирова Муяссар Убаевна, Каттаходжаева Махмуда Хамдамовна · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2026-03-27
The menopausal period is a physiological transition period in a woman's life, which occupies the period of time between the reproductive phase and old age.During this period, against the background of age-related…
Сафаров Алиаскар Турсунович, Сафарова Лола Алиаскаровна · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2026-05-25
Гуломаматова Тухтабону Акбарали кизи, Валиев Шухрат Насимович, Негмаджанов Баходур Болтаевич, Ганиев Фахриддин Истамкулович · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2026-03-27
This izohiye review summarizes contemporary management strategies for varicose vein disease in pregnancy when complicated by migratory thrombosis (migratory superficial thrombophlebitis). The review outlines diagnostic…