The COVID-19 pandemic has revealed previously unrecognized clinical features of infectious and inflammatory kidney diseases in pediatric patients. Objective: To determine the significance of tubuloglomerular abnormalities biomarkers (γ-GT, β2M, NGAL, KIM-1) in clinical and laboratory diagnostics in children with acute pyelonephritis after COVID-19. Methods. The study included 100 children with clinically and laboratory-confirmed acute pyelonephritis. The control group consisted of 25 apparently healthy children, matched for age and gender. Results. The study results revealed a statistically significant increase in urinary γ-GT, KIM-1, NGAL, and β₂-microglobulin concentrations compared to the control group. In patients in the first group, γ-GT levels were 4.57 times higher than the control group, KIM-1 levels were 3.77 times higher, NGAL levels were 25.96 times higher, and β₂M levels were 7.64 times higher. Conclusion. Determining the concentrations of these parameters allows us to identify early signs of tubulointerstitial damage, assess the activity of the pathological process in the renal tubular apparatus, and identify risk groups for chronic pyelonephritis.
| Mualliflar | Ахмеджанова Наргиза Исмаиловна, Шомурадова Шахноза Шавкатовна |
|---|---|
| Jurnal | Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) |
| Nashriyot | Самарқанд давлат тиббиёт университети |
| ISSN | 2017-2021 |
| Nashr sanasi | 2026-03-27 |
| Jild | 7 |
| Son | 1 |
| Til | Ingliz |
| Ilmiy soha | Tibbiyot |
| Indeksga qo‘shilgan | 2026-08-26 |
постковидные осложнения, острый пиелонефрит, тубулоинтерстициальные поражения, KIM-1, NGAL, β₂-микроглобулин, γ-ГТ., : post-COVID complications, acute pyelonephritis, tubulointerstitial lesions, KIM-1, NGAL, β₂-microglobulin, γ-GT., COVIDdan keyingi asoratlar, o'tkir pielonefrit, tubulointerstisial shikastlanishlar, KIM-1, NGAL, β₂-mikroglobulin, γ-GT. Ахмеджанова
| APA | Ахмеджанова Наргиза Исмаиловна, & Шомурадова Шахноза Шавкатовна (2026). PREDICTORS OF TUBULOINTERSTITIAL LESIONS IN ACUTE PYELONEPHRITIS IN CHILDREN. Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали), 7(1). https://tadqiqot.uz/index.php/uro/article/view/13331 |
|---|---|
| GOST (OAK) | Ахмеджанова Наргиза Исмаиловна, Шомурадова Шахноза Шавкатовна PREDICTORS OF TUBULOINTERSTITIAL LESIONS IN ACUTE PYELONEPHRITIS IN CHILDREN // Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали). – 2026. – T. 7, № 1. |
| MLA | Ахмеджанова Наргиза Исмаиловна, and Шомурадова Шахноза Шавкатовна. “PREDICTORS OF TUBULOINTERSTITIAL LESIONS IN ACUTE PYELONEPHRITIS IN CHILDREN.” Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали), 7(1), 2026. https://tadqiqot.uz/index.php/uro/article/view/13331 |
| Chicago | Ахмеджанова Наргиза Исмаиловна, and Шомурадова Шахноза Шавкатовна. “PREDICTORS OF TUBULOINTERSTITIAL LESIONS IN ACUTE PYELONEPHRITIS IN CHILDREN.” Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали), 7(1) (2026). https://tadqiqot.uz/index.php/uro/article/view/13331 |
| Harvard | Ахмеджанова Наргиза Исмаиловна, and Шомурадова Шахноза Шавкатовна (2026) ‘PREDICTORS OF TUBULOINTERSTITIAL LESIONS IN ACUTE PYELONEPHRITIS IN CHILDREN’, Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали), 7(1). https://tadqiqot.uz/index.php/uro/article/view/13331 |
| BibTeX | @article{article2026,
title = {PREDICTORS OF TUBULOINTERSTITIAL LESIONS IN ACUTE PYELONEPHRITIS IN CHILDREN},
author = {Ахмеджанова Наргиза Исмаиловна and Шомурадова Шахноза Шавкатовна},
journal = {Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали)},
year = {2026},
volume = {7},
number = {1},
url = {https://tadqiqot.uz/index.php/uro/article/view/13331}
} |
Boshqa maqola uchun iqtibos tayyorlash
Caesarean sections (CS) save the lives of mothers and babies, but the unjustified increase in the number of CS is alarming. Materials and methods. We examined data from maternity hospital reports across the country, as…
Obstetric hemorrhage remains one of the leading preventable causes of maternal mortality and severe maternal morbidity. Key contributors to adverse outcomes include delayed recognition of increasing blood loss, delayed…
Critical obstetric conditions are characterized by rapid deterioration of vital functions and require simultaneous achievement of two priorities: maternal stabilization and minimization of fetal risk. The most common…
Angular cheilitis is a common inflammatory disease of the oral mucosa often associated with systemic deficiency conditions. Pregnancy is accompanied by an increased demand for iron and B-group vitamins, the deficiency…
Clinical observations were conducted to characterize congenital anomalies of the reproductive organs in girls living in southern Uzbekistan. The study included a total of 50 patients who, between 2020 and 2025, were…
This izohiye review summarizes contemporary management strategies for varicose vein disease in pregnancy when complicated by migratory thrombosis (migratory superficial thrombophlebitis). The review outlines diagnostic…
The menopausal period is a physiological transition period in a woman's life, which occupies the period of time between the reproductive phase and old age.During this period, against the background of age-related…
This article is devoted to contemporary clinical approaches to the management of patients with benign tumors of the uterus and its adnexa in the setting of genital prolapse. The paper highlights etiological factors…
In recent years, the issue of the impact of environmental factors on human health has become one of the most pressing areas of research in medical and biological sciences. Pollution of the atmosphere, water, and soil…
The aim of the study is to investigate the prevalence and incidence of connective tissue dysplasia among pregnant women in primary health care and to develop a system for managing patients. The study was conducted at…
Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) — barcha maqolalar · 2026-yil arxivi
The aim of the work was an attempt to evaluate the effect of regional lymphatic antibiotic therapy (RLAT) on some indicators of the functional state of the kidneys in acute pyelonephritis that developed against the…
In almost 25% of patients, their progression continues, which leads to a change in the quality of life. Target . To evaluate the features of clinical and laboratory parameters in various forms of pyelonephritis in…
In the structure of renal pathology in childhood, a special place is occupied by glomerulonephritis. The aim of this work was to study the clinical features and evaluate laboratory parameters in children with primary…
Many authors state that COVID-19 infection can complicate treatment and increase mortality, mainly in individuals with kidney disease . Purpose of work: study and treatment of clinical and laboratory features of…
Настоящее исследование посвящено разработке алгоритма раннего выявления сенсоневральной тугоухости у детей с использованием методов полимеразной цепной реакции (ПЦР). Обследовано 235 детей с нарушениями слуха, из…
В статье представлены клинические аспекты и диагностические проблемы выявления сенсоневральной тугоухости у новорождённых с перинатальной патологией. Обследовано 115 новорождённых, из которых 35 перенесли асфиксию, а у…
Сенсоневральная тугоухость (СНТ) у детей остаётся одной из наиболее актуальных проблем современной оториноларингологии и медицинской генетики. Ранняя диагностика нарушений слуха играет ключевую роль в предупреждении…
Сенсоневральная тугоухость у новорождённых является одной из ведущих причин нарушения слухоречевого развития и ранней инвалидизации. Наиболее уязвимыми считаются дети, перенёсшие перинатальные осложнения, такие как…
Mazkur eksperimental tadqiqotda yuqori yog‘li ratsion va seftriaksonning lipid hamda uglevod almashinuviga alohida va birgalikdagi ta’siri 160 ta oq zotsiz erkak kalamushda o‘rganildi. Tajriba hayvonlari to‘rtta guruhga…
Мазкур тадқиқотда Тошкет вилоятидаги Ўрта Чирчиқ тумани 25-сонли, Бўка тумани 3-сонли ва 9-сонли давлат мактабгача таълим ташкилотларида 2025 йил ёз мавсумидаги таомномаларнинг озиқ-овқат маҳсулотлари билан…