Immunological characteristics of patients with comorbid bronchial asthma and type 2 diabetes mellitus

Ubaydullayeva N.N, Khaydarova F.A, Ismatullayeva S.S, Saidova S.Kh

Klinik fanlar yilnomasi · 2026-yil

Annotatsiya

The article presents a comparative analysis of cytokine profile characteristics in patients with bronchial asthma, type 2 diabetes mellitus, and their combination. The levels of IL-6 and IL-10, as key mediators of immune-inflammatory activation, were studied in relation to carbohydrate and lipid metabolism parameters, leptin, systemic inflammatory markers, and respiratory function. Statistical analysis demonstrated that the combination of bronchial asthma and type 2 diabetes mellitus was characterized by the most pronounced pro-inflammatory activity, accompanied by a simultaneous increase in the level of the anti-inflammatory cytokine IL-10. Strong immunometabolic associations were identified: leptin levels were positively associated with IL-6 and IL-10, as well as with atherogenic lipid profile parameters, and negatively associated with high-density lipoprotein (HDL) levels. IL-6 levels showed strong correlations with C-reactive protein (CRP) and IgE, while its concentration was significantly higher in the presence of pronounced hyperglycemia. Furthermore, increased IL-6 levels were accompanied by reduced respiratory function parameters, as confirmed by a strong negative correlation with forced vital capacity (FVC). Thus, the combination of bronchial asthma and type 2 diabetes mellitus forms a distinct immunometabolic phenotype in which hyperglycemia, dyslipidemia, and elevated leptin levels are associated with increased systemic inflammation and impaired functional status of the respiratory system.

Maqola ma’lumotlari
MualliflarUbaydullayeva N.N, Khaydarova F.A, Ismatullayeva S.S, Saidova S.Kh
JurnalKlinik fanlar yilnomasi
NashriyotБухоро давлат тиббиёт институти
ISSN2025-2026, 0009-0006
Nashr sanasi2026-09-09
Jild3
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-09-10

Maqolaning asl sahifasi

Kalit so‘zlar

bronchial asthma, type 2 diabetes mellitus, IL-6, IL-10, leptin, systemic inflammation, IgE, C-reactive protein, spirometry, бронхиальная астма, сахарный диабет 2 типа, ИЛ-6, ИЛ-10, лептин, системное воспаление, IgE, С-реактивный белок, спирометрия, bronxial astma, 2-tur qandli diabet, IL-6, IL-10, leptin, tizimli yallig‘lanish, IgE, C-reaktiv oqsil, spirometriya

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAUbaydullayeva N.N, Khaydarova F.A, Ismatullayeva S.S, & Saidova S.Kh (2026). IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH COMORBID BRONCHIAL ASTHMA AND TYPE 2 DIABETES MELLITUS. Klinik fanlar yilnomasi, 3(2). https://tadqiqot.uz/index.php/spjacd/article/view/15033
GOST (OAK)Ubaydullayeva N.N va b. IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH COMORBID BRONCHIAL ASTHMA AND TYPE 2 DIABETES MELLITUS // Klinik fanlar yilnomasi. – 2026. – T. 3, № 2.
MLAUbaydullayeva N.N, Khaydarova F.A, Ismatullayeva S.S, and Saidova S.Kh. “IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH COMORBID BRONCHIAL ASTHMA AND TYPE 2 DIABETES MELLITUS.” Klinik fanlar yilnomasi, 3(2), 2026. https://tadqiqot.uz/index.php/spjacd/article/view/15033
ChicagoUbaydullayeva N.N, Khaydarova F.A, Ismatullayeva S.S, and Saidova S.Kh. “IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH COMORBID BRONCHIAL ASTHMA AND TYPE 2 DIABETES MELLITUS.” Klinik fanlar yilnomasi, 3(2) (2026). https://tadqiqot.uz/index.php/spjacd/article/view/15033
HarvardUbaydullayeva N.N, Khaydarova F.A, Ismatullayeva S.S, and Saidova S.Kh (2026) ‘IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH COMORBID BRONCHIAL ASTHMA AND TYPE 2 DIABETES MELLITUS’, Klinik fanlar yilnomasi, 3(2). https://tadqiqot.uz/index.php/spjacd/article/view/15033
BibTeX
@article{ubaydullayevann2026,
  title = {IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH COMORBID BRONCHIAL ASTHMA AND TYPE 2 DIABETES MELLITUS},
  author = {Ubaydullayeva N.N and Khaydarova F.A and Ismatullayeva S.S and Saidova S.Kh},
  journal = {Klinik fanlar yilnomasi},
  year = {2026},
  volume = {3},
  number = {2},
  url = {https://tadqiqot.uz/index.php/spjacd/article/view/15033}
}

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