Synthesis of new derivatives of 5-FLUOROURACIL

OCHILOV, Shohzod, SHAKIRZYANOVA, Gulnаra, ESANOV, Rahmat, MATCHANOV, Alimjon

Ўзбекистон Миллий университети хабарлари · 2026-yil

Annotatsiya

5-Fluorouracil and its derivatives have been used for many years in the treatment of tumor diseases (gastrointestinal,gynecological, head and neck, breast cancer). 5-Fluorouracil against cancer it is a powerful agent and at the same time has manyharmful properties. In this work, in order to reduce the toxicity of 5-FU, it was first exposed to formalin and a compound of 5-FUwith methylol group was obtained. Then, by treating this compound with different carboxylic acids (formic, acetic and benzoic),derivatives of 5-FU were synthesized. The analysis of the obtained products was studied by IR, UV, HPLC and gaschromatograms.

Maqola ma’lumotlari
MualliflarOCHILOV, Shohzod, SHAKIRZYANOVA, Gulnаra, ESANOV, Rahmat, MATCHANOV, Alimjon
JurnalЎзбекистон Миллий университети хабарлари
NashriyotЎзбекистон Миллий университети
ISSN2181-7324, 3093-8996
Nashr sanasi2026-09-08
Jild3
Son3.2
Betlar315-318
TilIngliz
Ilmiy sohaKimyo
Indeksga qo‘shilgan2026-09-09

Maqolaning asl sahifasi

Kalit so‘zlar

5-Fluorouracil (5-FU), formic acid, acetic acid, benzoic acid, N,N'dicyclohexylcarbodiimide (DCC), N,N- dimethylaminopyridine-4 (DMAP), methanol., 5-фторурацил (5-ФУ), муравьиная кислота, уксусная кислота, бензойная кислота, N,N'- дициклогексилкарбодиимид (ДЦК), N,N-диметиламинопиридин-4 (ДМАП), метанол., 5-фторурацил (5-ФУ), муравьиная кислота, уксусная кислота, бензойная кислота, N,N'- дициклогексилкарбодиимид (ДЦК), N,N-диметиламинопиридин-4 (ДМАП), метанол.

Ilmiy soha

Kimyo

Iqtibos keltirish

APAOCHILOV, Shohzod, SHAKIRZYANOVA, Gulnаra, ESANOV, Rahmat, & MATCHANOV, Alimjon (2026). SYNTHESIS OF NEW DERIVATIVES OF 5-FLUOROURACIL. Ўзбекистон Миллий университети хабарлари, 3(3.2), 315-318. https://journals.nuu.uz/index.php/actanuuz/article/view/14817
GOST (OAK)OCHILOV, Shohzod va b. SYNTHESIS OF NEW DERIVATIVES OF 5-FLUOROURACIL // Ўзбекистон Миллий университети хабарлари. – 2026. – T. 3, № 3.2. – P. 315-318.
MLAOCHILOV, Shohzod, SHAKIRZYANOVA, Gulnаra, ESANOV, Rahmat, and MATCHANOV, Alimjon. “SYNTHESIS OF NEW DERIVATIVES OF 5-FLUOROURACIL.” Ўзбекистон Миллий университети хабарлари, 3(3.2), 315-318, 2026. https://journals.nuu.uz/index.php/actanuuz/article/view/14817
ChicagoOCHILOV, Shohzod, SHAKIRZYANOVA, Gulnаra, ESANOV, Rahmat, and MATCHANOV, Alimjon. “SYNTHESIS OF NEW DERIVATIVES OF 5-FLUOROURACIL.” Ўзбекистон Миллий университети хабарлари, 3(3.2), 315-318 (2026). https://journals.nuu.uz/index.php/actanuuz/article/view/14817
HarvardOCHILOV, Shohzod, SHAKIRZYANOVA, Gulnаra, ESANOV, Rahmat, and MATCHANOV, Alimjon (2026) ‘SYNTHESIS OF NEW DERIVATIVES OF 5-FLUOROURACIL’, Ўзбекистон Миллий университети хабарлари, 3(3.2), 315-318. https://journals.nuu.uz/index.php/actanuuz/article/view/14817
BibTeX
@article{ochilovshohzod2026,
  title = {SYNTHESIS OF NEW DERIVATIVES OF 5-FLUOROURACIL},
  author = {OCHILOV, Shohzod and SHAKIRZYANOVA, Gulnаra and ESANOV, Rahmat and MATCHANOV, Alimjon},
  journal = {Ўзбекистон Миллий университети хабарлари},
  year = {2026},
  volume = {3},
  number = {3.2},
  pages = {315-318},
  url = {https://journals.nuu.uz/index.php/actanuuz/article/view/14817}
}

Boshqa maqola uchun iqtibos tayyorlash

Ўзбекистон Миллий университети хабарлари jurnalidan boshqa maqolalar

Ўзбекистон Миллий университети хабарлари — barcha maqolalar · 2026-yil arxivi

Kimyo sohasidagi boshqa maqolalar

Kimyo sohasidagi OAK jurnallari