The role of matrix metalloproteinases (MMP-1, MMP-3, MMP-9) and their tissue inhibitors (timp) in the pathogenesis of intervertebral disc degeneration

Ёкубжонов Асилбек Абдувахоб угли

Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2026-yil

Annotatsiya

Intervertebral disc (IVD) degeneration is a key link in the pathogenesis of discogenic back pain, disc herniation, and Modic endplate changes. The central role in the destruction of the disc extracellular matrix is played by the family of matrix metalloproteinases (MMPs) - zinc-dependent endopeptidases capable of cleaving collagen, aggrecan, and other matrix components. This review systematizes current data on the role of three key enzymes - collagenase MMP-1, stromelysin MMP-3, and gelatinase MMP-9 - in the initiation and progression of the degenerative cascade, as well as the significance of their endogenous inhibitors (TIMP-1–4) in maintaining the catabolic-anabolic balance of the matrix. Particular attention is paid to the relationship between the MMP/TIMP system and the formation of Modic endplate changes, and to the prospects of using these biomarkers in the personalized diagnosis and therapy of degenerative spinal diseases.

Maqola ma’lumotlari
MualliflarЁкубжонов Асилбек Абдувахоб угли
JurnalЖурнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research
NashriyotБухоро давлат тиббиёт институти
Nashr sanasi2026-09-07
Jild7
Son5
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-09-08

Maqolaning asl sahifasi

Kalit so‘zlar

матриксные металлопротеиназы, ММП-1, ММП-3, ММП-9, тканевые ингибиторы металлопротеиназ, TIMP, дегенерация межпозвонкового диска, грыжа межпозвонкового диска, изменения по Modic, matrix metalloproteinases, MMP-1, MMP-3, MMP-9, tissue inhibitors of metalloproteinases, TIMP, intervertebral disc degeneration, intervertebral disc herniation, Modic changes, matriks metalloproteinazalar, MMP-1, MMP-3, MMP-9, metalloproteinazalarning to‘qima ingibitorlari, TIMP, umurtqalararo disk degeneratsiyasi, umurtqalararo disk churrasi, Modik o‘zgarishlari.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAЁкубжонов Асилбек Абдувахоб угли (2026). THE ROLE OF MATRIX METALLOPROTEINASES (MMP-1, MMP-3, MMP-9) AND THEIR TISSUE INHIBITORS (TIMP) IN THE PATHOGENESIS OF INTERVERTEBRAL DISC DEGENERATION. Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(5). https://tadqiqot.uz/index.php/neurology/article/view/14969
GOST (OAK)Ёкубжонов Асилбек Абдувахоб угли THE ROLE OF MATRIX METALLOPROTEINASES (MMP-1, MMP-3, MMP-9) AND THEIR TISSUE INHIBITORS (TIMP) IN THE PATHOGENESIS OF INTERVERTEBRAL DISC DEGENERATION // Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research. – 2026. – T. 7, № 5.
MLAЁкубжонов Асилбек Абдувахоб угли. “THE ROLE OF MATRIX METALLOPROTEINASES (MMP-1, MMP-3, MMP-9) AND THEIR TISSUE INHIBITORS (TIMP) IN THE PATHOGENESIS OF INTERVERTEBRAL DISC DEGENERATION.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(5), 2026. https://tadqiqot.uz/index.php/neurology/article/view/14969
ChicagoЁкубжонов Асилбек Абдувахоб угли. “THE ROLE OF MATRIX METALLOPROTEINASES (MMP-1, MMP-3, MMP-9) AND THEIR TISSUE INHIBITORS (TIMP) IN THE PATHOGENESIS OF INTERVERTEBRAL DISC DEGENERATION.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(5) (2026). https://tadqiqot.uz/index.php/neurology/article/view/14969
HarvardЁкубжонов Асилбек Абдувахоб угли (2026) ‘THE ROLE OF MATRIX METALLOPROTEINASES (MMP-1, MMP-3, MMP-9) AND THEIR TISSUE INHIBITORS (TIMP) IN THE PATHOGENESIS OF INTERVERTEBRAL DISC DEGENERATION’, Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(5). https://tadqiqot.uz/index.php/neurology/article/view/14969
BibTeX
@article{article2026,
  title = {THE ROLE OF MATRIX METALLOPROTEINASES (MMP-1, MMP-3, MMP-9) AND THEIR TISSUE INHIBITORS (TIMP) IN THE PATHOGENESIS OF INTERVERTEBRAL DISC DEGENERATION},
  author = {Ёкубжонов Асилбек Абдувахоб угли},
  journal = {Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research},
  year = {2026},
  volume = {7},
  number = {5},
  url = {https://tadqiqot.uz/index.php/neurology/article/view/14969}
}

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