According to modern studies it was found that in the nucleic acid loci of species belonging to the M. tuberculosis complex, mutations are most often found in all strains of seven structural genes KatG, inhA, kasA, ahpC, ndh, nat, and mshA. It has been established, according to molecular genetic studies, that the KatG gene produces an enzyme similar to catalase and peroxidase. The effect of the KatG enzyme on the resistance of mycobacteria (in particular, M. tuberculosis) to the drug isoniazid was evaluated. The drug isoniazid serves as a "destroyer" of mycolic acids in the shell of microbacteria, the KatG enzyme produced by mycobacteria during the mutation of the KatG gene, due to its catalase and peroxidase activity, activates the prodrug isoniazid, which further has a destructive effect on the cell wall of the M. tuberculosis complex. This article discusses aspects of antibiotic resistance of mycobacteria under the influence of their genetic mutations.
| Mualliflar | Nazarov , Jalolitdin Sulton, Rakhimov , Jamshid, Назаров , Жалолитдин Султон, Рахимов , Джамшид, Nazarov , Jalolitdin Sulton, Rahimov , Jamshid |
|---|---|
| Jurnal | Профилактическая медицина и здоровье |
| Nashriyot | Андижон давлат тиббиёт институти; In Science МЧЖ |
| ISSN | 2181-3663, 2004-2015 |
| Nashr sanasi | 2023-12-15 |
| Jild | 2 |
| Son | 6 |
| Betlar | 8-22 |
| Til | Ingliz |
| Ilmiy soha | Tibbiyot |
| Indeksga qo‘shilgan | 2026-08-26 |
генетические мутации, штаммы M. tuberculosis complex, изониазид, фермент KatG, ШЛУ-ТБ, МЛУ-ТБ, genetic mutations, M. tuberculosis complex strains, isoniazid, KatG enzyme, XDR-TB, MDR-TB, genetik mutatsiyalar, M. tuberculosis complex shtammlari, izoniazid, KatG fermenti, KeDQ-TB (keng dori qarshilik), KoʻDQ-TB (koʻp dori qarshilik)
| APA | Nazarov , Jalolitdin Sulton, Rakhimov , Jamshid, Назаров , Жалолитдин Султон, Рахимов , Джамшид, Nazarov , Jalolitdin Sulton, & Rahimov , Jamshid (2023). Influence of dynamics of MTBC genome mutations on formation of drug resistance in mycobacterial strains (a review). Профилактическая медицина и здоровье, 2(6), 8-22. https://inlibrary.uz/index.php/preventive-medicine/article/view/85113 |
|---|---|
| GOST (OAK) | Nazarov , Jalolitdin Sulton va b. Influence of dynamics of MTBC genome mutations on formation of drug resistance in mycobacterial strains (a review) // Профилактическая медицина и здоровье. – 2023. – T. 2, № 6. – P. 8-22. |
| MLA | Nazarov , Jalolitdin Sulton, Rakhimov , Jamshid, Назаров , Жалолитдин Султон, Рахимов , Джамшид, Nazarov , Jalolitdin Sulton, and Rahimov , Jamshid. “Influence of dynamics of MTBC genome mutations on formation of drug resistance in mycobacterial strains (a review).” Профилактическая медицина и здоровье, 2(6), 8-22, 2023. https://inlibrary.uz/index.php/preventive-medicine/article/view/85113 |
| Chicago | Nazarov , Jalolitdin Sulton, Rakhimov , Jamshid, Назаров , Жалолитдин Султон, Рахимов , Джамшид, Nazarov , Jalolitdin Sulton, and Rahimov , Jamshid. “Influence of dynamics of MTBC genome mutations on formation of drug resistance in mycobacterial strains (a review).” Профилактическая медицина и здоровье, 2(6), 8-22 (2023). https://inlibrary.uz/index.php/preventive-medicine/article/view/85113 |
| Harvard | Nazarov , Jalolitdin Sulton, Rakhimov , Jamshid, Назаров , Жалолитдин Султон, Рахимов , Джамшид, Nazarov , Jalolitdin Sulton, and Rahimov , Jamshid (2023) ‘Influence of dynamics of MTBC genome mutations on formation of drug resistance in mycobacterial strains (a review)’, Профилактическая медицина и здоровье, 2(6), 8-22. https://inlibrary.uz/index.php/preventive-medicine/article/view/85113 |
| BibTeX | @article{nazarovjalolitdinsulton2023,
title = {Influence of dynamics of MTBC genome mutations on formation of drug resistance in mycobacterial strains (a review)},
author = {Nazarov , Jalolitdin Sulton and Rakhimov , Jamshid and Назаров , Жалолитдин Султон and Рахимов , Джамшид and Nazarov , Jalolitdin Sulton and Rahimov , Jamshid},
journal = {Профилактическая медицина и здоровье},
year = {2023},
volume = {2},
number = {6},
pages = {8-22},
url = {https://inlibrary.uz/index.php/preventive-medicine/article/view/85113}
} |
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