Relevance. Due to the high disability, many authors consider neovascular glaucoma an important and urgent problem of modern ophthalmology. The aim of the study was to study the distribution frequency of FII, FV, MTHFR genes’ mutant alleles in patients with post-thrombotic neovascular glaucoma. Material and methods of research. 85 patients (85 eyes) with post-thrombotic neovascular glaucoma, observed at RSSPMCEM and 60 conditionally healthy donors of uzbek nationality, who had no history of thrombotic events and permanently residing in different regions of the Republic of Uzbekistan, underwent ophthalmological and molecular genetic methods of research. Results. The risk of the disease development in patients with a mutation in the prothrombin gene was about 0.9% (OR = 0.89). The frequency of the F V gene mutation occurrence among patients’ groups was 5.7% without a clear predominance among men and women. The overall frequency of the C677T mutation in the MTHFR gene for the patient population was 60.0% (45.7% heterozygous and 14.3% homozygous). Conclusion. among the three explored genetic markers, only the C677T MTHFR mutation, especially the homozygous form, is associated with an increased risk of primary and recurrent thrombosis of the central retinal vein and its branches, and the development of postthrombotic neovascular glaucoma in the presence of provoking factors.
| Mualliflar | М.Х. Каримова, С. И. Абдуллаева, А. А. Абдушукурова, У.Ш. Хамраева |
|---|---|
| Jurnal | Передовая Офтальмология |
| Nashr sanasi | 2023-02-22 |
| Jild | 1 |
| Son | 1 |
| Betlar | 121-124 |
| Til | ru |
| DOI | 10.57231/j.ao.2023.1.1.028 |
DOI: 10.57231/j.ao.2023.1.1.028 · Maqolaning asl sahifasi · PDF
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