Enantioselective alkynylation of some cyclical ketones by 3,3′-diphenylbinaphtol dilithium

Otamuxamedova Guzal, Ziyadullayev Odiljon, Shmid Elena, Maniecki Tomash

Kimyo va kimyo texnologiyasi · 2019-yil

Annotatsiya

Synthesis of new biologically-active acetylene alcohols containing in composition of their molecules aromatical, cyclical and hydroxyl-groups and also triple bond by reaction of enantioselective alkylation of some cyclic ketones such as cyclohexanon, 2-methylcyclohexanon, menton and camphora with phenylacetylene in the presence of 3,3′-diphenylbinaphtol has been investigated. New methods of synthesis of acetylene alcohols and mechanisms of corresponding reactions were preposed. Influence of nature of initial compounds, catalysts and solvents on carring out of reaction and yields of products has been determined. On the base experimental results optimal condition of carring out of reactions have been also determined. It was shown that in solution of TGF the mole ratio phenylacetylene: keton 1:2, temperatupe 0 oC, duration of reaction 120 min. are the optimal conditions of carring out of investigated reactions. Structure of synthesized alcohols: 1-(2-phenylethynil)cyclohexanol, 2-methyl-1-(2- phenylethynil)-cyclohexanol, 2-isopropyl-5-methyl-1-(2-phenylethynil)cyclohexanol and 1,7,7-threemethyl-2-(2-phenylethynil) biciclo[2,2,1]-heptanol-2 has been proved and also their purity was determined by some physico-chemical methods.

Maqola ma’lumotlari
MualliflarOtamuxamedova Guzal, Ziyadullayev Odiljon, Shmid Elena, Maniecki Tomash
JurnalKimyo va kimyo texnologiyasi
NashriyotТошкент кимё-технология институти
ISSN1992-9498, 2181-1121
Nashr sanasi2019-11-11
Jild2019
Son2
TilIngliz
Ilmiy sohaKimyo
DOI10.70189/1992-9498.1111
Indeksga qo‘shilgan2026-09-02

DOI: 10.70189/1992-9498.1111 · Maqolaning asl sahifasi

Ilmiy soha

Kimyo

Iqtibos keltirish

APAOtamuxamedova Guzal, Ziyadullayev Odiljon, Shmid Elena, & Maniecki Tomash (2019). Enantioselective alkynylation of some cyclical ketones by 3,3′-diphenylbinaphtol dilithium. Kimyo va kimyo texnologiyasi, 2019(2). https://doi.org/10.70189/1992-9498.1111
GOST (OAK)Otamuxamedova Guzal va b. Enantioselective alkynylation of some cyclical ketones by 3,3′-diphenylbinaphtol dilithium // Kimyo va kimyo texnologiyasi. – 2019. – T. 2019, № 2. – DOI: 10.70189/1992-9498.1111.
MLAOtamuxamedova Guzal, Ziyadullayev Odiljon, Shmid Elena, and Maniecki Tomash. “Enantioselective alkynylation of some cyclical ketones by 3,3′-diphenylbinaphtol dilithium.” Kimyo va kimyo texnologiyasi, 2019(2), 2019. https://doi.org/10.70189/1992-9498.1111
ChicagoOtamuxamedova Guzal, Ziyadullayev Odiljon, Shmid Elena, and Maniecki Tomash. “Enantioselective alkynylation of some cyclical ketones by 3,3′-diphenylbinaphtol dilithium.” Kimyo va kimyo texnologiyasi, 2019(2) (2019). https://doi.org/10.70189/1992-9498.1111
HarvardOtamuxamedova Guzal, Ziyadullayev Odiljon, Shmid Elena, and Maniecki Tomash (2019) ‘Enantioselective alkynylation of some cyclical ketones by 3,3′-diphenylbinaphtol dilithium’, Kimyo va kimyo texnologiyasi, 2019(2). https://doi.org/10.70189/1992-9498.1111
BibTeX
@article{otamuxamedovaguzal2019,
  title = {Enantioselective alkynylation of some cyclical ketones by 3,3′-diphenylbinaphtol dilithium},
  author = {Otamuxamedova Guzal and Ziyadullayev Odiljon and Shmid Elena and Maniecki Tomash},
  journal = {Kimyo va kimyo texnologiyasi},
  year = {2019},
  volume = {2019},
  number = {2},
  doi = {10.70189/1992-9498.1111},
  url = {https://doi.org/10.70189/1992-9498.1111}
}

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