By periodate oxidation of inulin, samples of polyaldehydinulin with varying degrees of oxidation have been obtained. The obtained polyaldehydinulines were used for the chemical modification of the low molecular weight drug adriamycin. It has been found that the quantitative content of adriamycin in the reaction products depends on the degree of oxidation of polyaldehydinulin. Using IR-spectroscopy, it has been proven that the chemical binding of adriamycin to polyaldehydinulin occurs through covalent azomethine bonds. When synthesized inulin-adriamycin was hydrolyzed in an acidic (pH 2.0) and slightly alkaline environment (pH 7.4), it has been proven that the drug has a prolonged release. The presence of adriamycin in the composition of polyaldehydinulin has been also substantiated by UV spectroscopy.
| Mualliflar | G. R. Rakhmonberdiev, Komila Ibragimova, Jasur Tilakov, Arslon Khusenov, A.M. Bocheka |
|---|---|
| Jurnal | Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi |
| Nashriyot | Самарқанд давлат университети |
| ISSN | 2091-5446, 2181-1296 |
| Nashr sanasi | 2025-03-29 |
| Jild | 1 |
| Son | 1 |
| Betlar | 128-133 |
| Til | Ingliz |
| Ilmiy soha | Kimyo |
| DOI | 10.59251/2181-1296.2025.v1.149.1.3393 |
| Indeksga qo‘shilgan | 2026-09-02 |
DOI: 10.59251/2181-1296.2025.v1.149.1.3393 · Maqolaning asl sahifasi
| APA | G. R. Rakhmonberdiev, Komila Ibragimova, Jasur Tilakov, Arslon Khusenov, & A.M. Bocheka (2025). APPLICATION OF POLYALDEHYDINULINE FOR MODIFICATION OF LOW MOLECULAR DRUGS. Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi, 1(1), 128-133. https://doi.org/10.59251/2181-1296.2025.v1.149.1.3393 |
|---|---|
| GOST (OAK) | G. R. Rakhmonberdiev va b. APPLICATION OF POLYALDEHYDINULINE FOR MODIFICATION OF LOW MOLECULAR DRUGS // Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi. – 2025. – T. 1, № 1. – P. 128-133. – DOI: 10.59251/2181-1296.2025.v1.149.1.3393. |
| MLA | G. R. Rakhmonberdiev, Komila Ibragimova, Jasur Tilakov, Arslon Khusenov, and A.M. Bocheka. “APPLICATION OF POLYALDEHYDINULINE FOR MODIFICATION OF LOW MOLECULAR DRUGS.” Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi, 1(1), 128-133, 2025. https://doi.org/10.59251/2181-1296.2025.v1.149.1.3393 |
| Chicago | G. R. Rakhmonberdiev, Komila Ibragimova, Jasur Tilakov, Arslon Khusenov, and A.M. Bocheka. “APPLICATION OF POLYALDEHYDINULINE FOR MODIFICATION OF LOW MOLECULAR DRUGS.” Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi, 1(1), 128-133 (2025). https://doi.org/10.59251/2181-1296.2025.v1.149.1.3393 |
| Harvard | G. R. Rakhmonberdiev, Komila Ibragimova, Jasur Tilakov, Arslon Khusenov, and A.M. Bocheka (2025) ‘APPLICATION OF POLYALDEHYDINULINE FOR MODIFICATION OF LOW MOLECULAR DRUGS’, Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi, 1(1), 128-133. https://doi.org/10.59251/2181-1296.2025.v1.149.1.3393 |
| BibTeX | @article{grrakhmonberdiev2025,
title = {APPLICATION OF POLYALDEHYDINULINE FOR MODIFICATION OF LOW MOLECULAR DRUGS},
author = {G. R. Rakhmonberdiev and Komila Ibragimova and Jasur Tilakov and Arslon Khusenov and A.M. Bocheka},
journal = {Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi},
year = {2025},
volume = {1},
number = {1},
pages = {128-133},
doi = {10.59251/2181-1296.2025.v1.149.1.3393},
url = {https://doi.org/10.59251/2181-1296.2025.v1.149.1.3393}
} |
Boshqa maqola uchun iqtibos tayyorlash
In this paper, the characteristic vibrational modes of aniline were analyzed using polarized Raman and two dimensional Raman correlation spectroscopy methods. Polarized Raman spectra revealed the presence of anomalous…
This paper investigates the self-similar analysis of a system of equations given by a diffusion process. The study focuses on a coupled system of nonlinear parabolic partial differential equations (PDEs) that describe…
It is known that the theorems of Desargues and Steiner are the main theorems of projective geometry. In all sources, the proofs of these theorems are given by axiomatic methods. Since the axiomatic method consists of…
In this work, interactions of glyoxal in ethyl alcohol, water and dimethylsulfoxide (DMSO) complexes and their spectral manifestations were studied using ab-initio calculations. The molecular forces, bond structure and…
The structural, electronic, and bonding properties of hydrogen-bonded complexes between formamide and urea in different stoichiometric ratios (1:1, 1:2, and 2:1) have been investigated using Density Functional Theory…
In this work, the synthesis of iron ( Fe(II)), cobalt (Co(II)) and zinc (Zn(II)) ion complexes with flavonoids quercetin and rutin was studied and their stability constants at different pH values were estimated. The…
The effect of a mixed solvent of water - isopropanol was studied on the relative volume of polyvinyl alcohol gel in solutions of various electrolytes of different concentrations. Kinetic curves of the change in the…
A novel series of 6-bromo-benzo[2,1 b]pyrimidin-4-thiones were synthesized. Thiones of the tricyclic pyrimidinones are obtained via a conversion procedure, where the C=O functional group is successfully converted into…
In the present research note, we have derived the explicit expression for the perihelion precession and the deflection angle of light by the gravitational object. The explicit expression for the trajectory of the planet…
This paper presents the results of obtaining a thin-film hybrid structure on the surface of a single-crystal silicon wafer with a fairly thin layer of silicon dioxide (SiO2) (~2÷4 nm), in which a thin perovskite layer…
Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi — barcha maqolalar · 2025-yil arxivi
Ushbu maqolada ingliz tilini xorijiy til sifatida o‘rganishda yangi so‘zlarni vizual va verbal usullar orqali o‘zlashtirish samaradorligi tahlil qilinadi. Tadqiqotda vizual materiallar (rasmlar, grafik tasvirlar va…
Ushbu maqolada mashina tarjimasi (MT) vositalarining Toshkent Kimyo xalqaro universitetida tahsil olayotgan o‘zbek-ingliz ikki tilli talabalarning ingliz tilidagi yozma ishlarida uchraydigan xatolarga ta’siri…
Maqolada 1892-yilda “Туркестанские ведомости” gazetasida chop etilgan Sattorxon Abdulg'afforovning “Qo'qon xonligining ruslar tomonidan istilo etilishidan oldingi ichki ahvoli haqida qisqacha ocherk” asarining…
This article examines the linguistic units and metaphorical fields that structure English ecological discourse — the texts that construct public understanding of nature and environmental crisis. Drawing on Conceptual…
Maqolada 1929–1930-yillardan boshlab O‘zbekiston SSRda amalga oshirilgan yalpi kollektivlashtirish, “quloqlarni sinf sifatida tugatish” siyosati va majburiy surgunning mahalliy jamiyat hayotiga ta’siri Farg‘ona vodiysi…
Amudaryo quyi oqimidagi sugʻoriladigan hududlarda qishloq xoʻjaligi qurgʻoqchiligini asosan yogʻin emas, balki daryodan olinadigan suv hajmi belgilaydi. Tadqiqotda Xorazm viloyatida bir yillik (2000, 2008, 2011) va…