The synthesis of novel thieno[3,2-d]pyrimidine derivatives started with the reaction of 5-bromo-2 chlorobenzonitrile with ethyl-2-mercaptoacetate to give the compound AT-2. The addition of lactames to the formed AT-2 followed by cyclization gave the compound AR-05. The amination reaction was then used to facilitate the formation of a C-C bond. The intermediate AR-05 was formed under a base in dioxane in the presence of aromatic amines and a palladium catalyst, forming a new nitrogen-carbon bond. AR-58-1 and AR-82 were synthesized as end products. The structure of the new compounds was studied by analyzing the results obtained by studying their physical and physico-chemical properties.
| Mualliflar | A. Buronov, Azizbek Nasrullaev, Khurshed Bozorov, N. Lifei, Haji Akber Aisa |
|---|---|
| Jurnal | Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi |
| Nashr sanasi | 2025-03-29 |
| Jild | 1 |
| Son | 1 |
| Betlar | 12-17 |
| Til | en |
| DOI | 10.59251/2181-1296.2025.v1.149.2.3208 |
DOI: 10.59251/2181-1296.2025.v1.149.2.3208 · Maqolaning asl sahifasi
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