Synthesis, acetylcholinesterase and butyrylcholinesterase inhibitory activity of novel tricyclic 1-PHENYL-1,6,7,8-TETRAHYDRO-4H- PYRAZOLO[3,4-d]PYRROLO[1,2-a]PYRIMIDIN-4-ONE

S a l i e v a G B, J u m a e v a M E, K h o l i k o v T S, A i s a H A, B o z o r o v K h A

Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi · 2021-yil

Annotatsiya

A convenient synthesis of novel tricyclic annulated pyrimidinone, namely 1-phenyl- 1,6,7,8-tetrahydro-4 H -pyrazolo[3,4- d ]pyrrolo[1,2- a ]pyrimidin-4-one was described herein. Cyclization was provided via A-ring modification of deoxyvasicinone (natural product). Biological activities of this compound reveal promising acetylcholinesterase inhibitory activity of 82.48±0.76 %, while showed moderate butyrylcholinesterase inhibitory activity

Maqola ma’lumotlari
MualliflarS a l i e v a G B, J u m a e v a M E, K h o l i k o v T S, A i s a H A, B o z o r o v K h A
JurnalSamarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi
NashriyotСамарқанд давлат университети
ISSN2091-5446, 2181-1296
Nashr sanasi2021-02-22
Jild1
Son125/2
Betlar1-7
TilIngliz
Ilmiy sohaKimyo
DOI10.59251/2181-1296.v1.1252.948
Indeksga qo‘shilgan2026-09-02

DOI: 10.59251/2181-1296.v1.1252.948 · Maqolaning asl sahifasi · PDF

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Iqtibos keltirish

APAS a l i e v a G B, J u m a e v a M E, K h o l i k o v T S, A i s a H A, & B o z o r o v K h A (2021). SYNTHESIS, ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORY ACTIVITY OF NOVEL TRICYCLIC 1-PHENYL-1,6,7,8-TETRAHYDRO-4H- PYRAZOLO[3,4-d]PYRROLO[1,2-a]PYRIMIDIN-4-ONE. Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi, 1(125/2), 1-7. https://doi.org/10.59251/2181-1296.v1.1252.948
GOST (OAK)S a l i e v a G B va b. SYNTHESIS, ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORY ACTIVITY OF NOVEL TRICYCLIC 1-PHENYL-1,6,7,8-TETRAHYDRO-4H- PYRAZOLO[3,4-d]PYRROLO[1,2-a]PYRIMIDIN-4-ONE // Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi. – 2021. – T. 1, № 125/2. – P. 1-7. – DOI: 10.59251/2181-1296.v1.1252.948.
MLAS a l i e v a G B, J u m a e v a M E, K h o l i k o v T S, A i s a H A, and B o z o r o v K h A. “SYNTHESIS, ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORY ACTIVITY OF NOVEL TRICYCLIC 1-PHENYL-1,6,7,8-TETRAHYDRO-4H- PYRAZOLO[3,4-d]PYRROLO[1,2-a]PYRIMIDIN-4-ONE.” Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi, 1(125/2), 1-7, 2021. https://doi.org/10.59251/2181-1296.v1.1252.948
ChicagoS a l i e v a G B, J u m a e v a M E, K h o l i k o v T S, A i s a H A, and B o z o r o v K h A. “SYNTHESIS, ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORY ACTIVITY OF NOVEL TRICYCLIC 1-PHENYL-1,6,7,8-TETRAHYDRO-4H- PYRAZOLO[3,4-d]PYRROLO[1,2-a]PYRIMIDIN-4-ONE.” Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi, 1(125/2), 1-7 (2021). https://doi.org/10.59251/2181-1296.v1.1252.948
HarvardS a l i e v a G B, J u m a e v a M E, K h o l i k o v T S, A i s a H A, and B o z o r o v K h A (2021) ‘SYNTHESIS, ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORY ACTIVITY OF NOVEL TRICYCLIC 1-PHENYL-1,6,7,8-TETRAHYDRO-4H- PYRAZOLO[3,4-d]PYRROLO[1,2-a]PYRIMIDIN-4-ONE’, Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi, 1(125/2), 1-7. https://doi.org/10.59251/2181-1296.v1.1252.948
BibTeX
@article{salievagb2021,
  title = {SYNTHESIS, ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORY ACTIVITY OF NOVEL TRICYCLIC 1-PHENYL-1,6,7,8-TETRAHYDRO-4H- PYRAZOLO[3,4-d]PYRROLO[1,2-a]PYRIMIDIN-4-ONE},
  author = {S a l i e v a G B and J u m a e v a M E and K h o l i k o v T S and A i s a H A and B o z o r o v K h A},
  journal = {Samarqand davlat universiteti ilmiy tadqiqotlar axborotnomasi},
  year = {2021},
  volume = {1},
  number = {125/2},
  pages = {1-7},
  doi = {10.59251/2181-1296.v1.1252.948},
  url = {https://doi.org/10.59251/2181-1296.v1.1252.948}
}

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