Extraintestinal signs, pathogenesis and genetic predictors of ulcerative colitis

Maxkamov Mansurjon Maxmudjonovich, Zakirova Umida Irkinovna, Махкамов Мансуржон Махмуджонович, Закирова Умида Иркиновна, Maxkamov Mansurjon Maxmudjonovich, Zakirova Umida Irkinovna

Research Focus · 2025-yil

Annotatsiya

Ulcerative colitis (UC) is a systemic disease that involves not only the intestine but the whole organism, in which extraintestinal manifestations (EIM) are frequent and in some cases appear before the intestinal symptoms. This article covers the spectrum of EIM in UC (musculoskeletal system, eyes, skin, hepatobiliary system) and modern views on their pathogenesis. Immunological mechanisms - T-cell dysregulation, molecular mimicry, the cytokine flow (TNF-α, IL-1, IL-6) and bacterial translocation associated with disruption of the intestinal barrier - play a leading role in the development of EIM. Genetic predictors include the HLA complex (among them HLA-B27, HLA-DRB10103, HLA-B8/DR3) and HLA-independent loci, as well as the familial concordances reported in GWAS studies. Clinically, UC is noted to be accompanied by peripheral and axial arthritis, enthesitis, osteopenia/osteoporosis and steroid-induced myopathy; ophthalmological complications (episcleritis, uveitis); skin changes (erythema nodosum, pyoderma gangrenosum, Sweet's syndrome), as well as hepatobiliary lesions (primary sclerosing cholangitis, autoimmune hepatitis). The fact that EIM are sometimes independent of intestinal activity complicates diagnosis and treatment. The article demonstrates the importance of multidisciplinary vigilance, early screening, and individualized therapy based on the genetic and clinical phenotype (choice of biological agents). This approach serves to reduce complications and to improve the patient's long-term outcomes.

Maqola ma’lumotlari
MualliflarMaxkamov Mansurjon Maxmudjonovich, Zakirova Umida Irkinovna, Махкамов Мансуржон Махмуджонович, Закирова Умида Иркиновна, Maxkamov Mansurjon Maxmudjonovich, Zakirova Umida Irkinovna
JurnalResearch Focus
NashriyotВетеринария ИТИ ва “Илм-фан ва инновациялар академияси” МЧЖ
ISSN2181-3833
Nashr sanasi2025-09-05
Jild4
Son8
Betlar61-66
TilIngliz
Ilmiy sohaVeterinariya
DOI10.66073/researchfocus.v4i8.1750
Indeksga qo‘shilgan2026-09-08

DOI: 10.66073/researchfocus.v4i8.1750 · Maqolaning asl sahifasi

Kalit so‘zlar

НАК, внекишечные проявления, воспалительное заболевание кишечника, иммунопатогенез, цитокины, молекулярная мимикрия, HLA-B27, HLA- DRB10103, первичный склерозирующий холангит, увеит, гангренозная пиодермия, узловатая эритема, генетические предикторы, персонализированная терапия, UC, extraintestinal manifestations, inflammatory bowel disease, immunopathogenesis, cytokines, molecular mimicry, HLA-B27, HLA-DRB10103, primary sclerosing cholangitis, uveitis, pyoderma gangrenosum, erythema nodosum, genetic predictors, personalized therapy, NYaK, ekstraintestinal belgilar, ichak yallig'lanish kasalliklari, immunopatogenez, sitokinlar, molekulyar mimikriya, HLA-B27, HLA-DRB10103, birlamchi sklerozlovchi xolangit, uveit, gangrenozli piodermiya, tugunli eritema, genetik prediktorlar, personallashtirilgan terapiya

Ilmiy soha

Veterinariya

Iqtibos keltirish

APAMaxkamov Mansurjon Maxmudjonovich, Zakirova Umida Irkinovna, Махкамов Мансуржон Махмуджонович, Закирова Умида Иркиновна, Maxkamov Mansurjon Maxmudjonovich, & Zakirova Umida Irkinovna (2025). EXTRAINTESTINAL SIGNS, PATHOGENESIS AND GENETIC PREDICTORS OF ULCERATIVE COLITIS. Research Focus, 4(8), 61-66. https://doi.org/10.66073/researchfocus.v4i8.1750
GOST (OAK)Maxkamov Mansurjon Maxmudjonovich va b. EXTRAINTESTINAL SIGNS, PATHOGENESIS AND GENETIC PREDICTORS OF ULCERATIVE COLITIS // Research Focus. – 2025. – T. 4, № 8. – P. 61-66. – DOI: 10.66073/researchfocus.v4i8.1750.
MLAMaxkamov Mansurjon Maxmudjonovich, Zakirova Umida Irkinovna, Махкамов Мансуржон Махмуджонович, Закирова Умида Иркиновна, Maxkamov Mansurjon Maxmudjonovich, and Zakirova Umida Irkinovna. “EXTRAINTESTINAL SIGNS, PATHOGENESIS AND GENETIC PREDICTORS OF ULCERATIVE COLITIS.” Research Focus, 4(8), 61-66, 2025. https://doi.org/10.66073/researchfocus.v4i8.1750
ChicagoMaxkamov Mansurjon Maxmudjonovich, Zakirova Umida Irkinovna, Махкамов Мансуржон Махмуджонович, Закирова Умида Иркиновна, Maxkamov Mansurjon Maxmudjonovich, and Zakirova Umida Irkinovna. “EXTRAINTESTINAL SIGNS, PATHOGENESIS AND GENETIC PREDICTORS OF ULCERATIVE COLITIS.” Research Focus, 4(8), 61-66 (2025). https://doi.org/10.66073/researchfocus.v4i8.1750
HarvardMaxkamov Mansurjon Maxmudjonovich, Zakirova Umida Irkinovna, Махкамов Мансуржон Махмуджонович, Закирова Умида Иркиновна, Maxkamov Mansurjon Maxmudjonovich, and Zakirova Umida Irkinovna (2025) ‘EXTRAINTESTINAL SIGNS, PATHOGENESIS AND GENETIC PREDICTORS OF ULCERATIVE COLITIS’, Research Focus, 4(8), 61-66. https://doi.org/10.66073/researchfocus.v4i8.1750
BibTeX
@article{maxkamovmansurjonmaxmudjonovich2025,
  title = {EXTRAINTESTINAL SIGNS, PATHOGENESIS AND GENETIC PREDICTORS OF ULCERATIVE COLITIS},
  author = {Maxkamov Mansurjon Maxmudjonovich and Zakirova Umida Irkinovna and Махкамов Мансуржон Махмуджонович and Закирова Умида Иркиновна and Maxkamov Mansurjon Maxmudjonovich and Zakirova Umida Irkinovna},
  journal = {Research Focus},
  year = {2025},
  volume = {4},
  number = {8},
  pages = {61-66},
  doi = {10.66073/researchfocus.v4i8.1750},
  url = {https://doi.org/10.66073/researchfocus.v4i8.1750}
}

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