Decoding the umod gene: implications for chronic kidney disease through genetic mechanisms, diagnostics, and therapeutic innovations

Tashkenbayeva, Eleonora, Esankulov, Mukhammad, Ташкенбаева, Элеонора, Эсанкулов, Мухаммад, Tashkenbayeva, Eleonora, Esankulov, Mukhammad

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi · 2025-yil

Annotatsiya

This review examines recent advances in the study of UMOD genetic variations, their functional consequences, and their impact on CKD pathogenesis. It also discusses the potential clinical applications of UMOD as a predictive biomarker for early CKD detection, risk stratification, and targeted interventions. The development of transcriptomic, proteomic, and metabolomic approaches allows for a more comprehensive study of UMOD function and its interactions with other genetic and metabolic pathways. Chronic kidney disease (CKD) is a growing global health concern, affecting millions of people worldwide. Genetic factors play a crucial role in the etiology and progression of CKD, influencing susceptibility, disease severity, and treatment response. Among these factors, the UMOD gene, which encodes the glycoprotein uromodulin, is recognized as a key regulator of kidney function, tubular integrity, and disease susceptibility. UMOD polymorphisms affect kidney function by altering sodium transport, modulating immune responses, and regulating oxidative stress, thereby contributing to hypertension, nephron damage, and CKD progression. Recent GWAS (genome-wide association studies) have confirmed the association between UMOD polymorphisms and an increased risk of CKD and its related complications. Additionally, a significant correlation has been identified between UMOD and hyperuricemia, as uromodulin plays a crucial role in uric acid transport and excretion. Conclusion: Personalized medicine based on UMOD genotyping opens new opportunities for individualized risk assessment, tailored pharmacotherapy, and lifestyle modifications to slow CKD progression. Additionally, promising therapeutic strategies are being developed, including pharmacological modulation of UMOD expression and gene therapy.The integration of genetic knowledge with clinical applications highlights the significance of UMOD in CKD pathogenesis and positions it as a promising target for precision nephrology, potentially improving clinical outcomes and optimizing patient management strategies.

Maqola ma’lumotlari
MualliflarTashkenbayeva, Eleonora, Esankulov, Mukhammad, Ташкенбаева, Элеонора, Эсанкулов, Мухаммад, Tashkenbayeva, Eleonora, Esankulov, Mukhammad
JurnalMedical science of Uzbekistan / O'zbekiston tibbiyot ilmi
NashriyotАндижон давлат тиббиёт институти
ISSN2181-3612
Nashr sanasi2025-02-26
Jild4
Son1
Betlar17-21
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-3612-2025-1-17-21
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-3612-2025-1-17-21 · Maqolaning asl sahifasi

Kalit so‘zlar

UMOD gene, uromodulin, chronic kidney disease, genetic variations, biomarkers, ген UMOD, уромодулин, хроническая болезнь почек, генетические вариации, биомаркеры, UMOD geni, uromodulin, surunkali buyrak kasalligi, genetik variantlar, biomarkerlar

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APATashkenbayeva, Eleonora, Esankulov, Mukhammad, Ташкенбаева, Элеонора, Эсанкулов, Мухаммад, Tashkenbayeva, Eleonora, & Esankulov, Mukhammad (2025). DECODING THE UMOD GENE: IMPLICATIONS FOR CHRONIC KIDNEY DISEASE THROUGH GENETIC MECHANISMS, DIAGNOSTICS, AND THERAPEUTIC INNOVATIONS. Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(1), 17-21. https://doi.org/10.56121/2181-3612-2025-1-17-21
GOST (OAK)Tashkenbayeva, Eleonora va b. DECODING THE UMOD GENE: IMPLICATIONS FOR CHRONIC KIDNEY DISEASE THROUGH GENETIC MECHANISMS, DIAGNOSTICS, AND THERAPEUTIC INNOVATIONS // Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi. – 2025. – T. 4, № 1. – P. 17-21. – DOI: 10.56121/2181-3612-2025-1-17-21.
MLATashkenbayeva, Eleonora, Esankulov, Mukhammad, Ташкенбаева, Элеонора, Эсанкулов, Мухаммад, Tashkenbayeva, Eleonora, and Esankulov, Mukhammad. “DECODING THE UMOD GENE: IMPLICATIONS FOR CHRONIC KIDNEY DISEASE THROUGH GENETIC MECHANISMS, DIAGNOSTICS, AND THERAPEUTIC INNOVATIONS.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(1), 17-21, 2025. https://doi.org/10.56121/2181-3612-2025-1-17-21
ChicagoTashkenbayeva, Eleonora, Esankulov, Mukhammad, Ташкенбаева, Элеонора, Эсанкулов, Мухаммад, Tashkenbayeva, Eleonora, and Esankulov, Mukhammad. “DECODING THE UMOD GENE: IMPLICATIONS FOR CHRONIC KIDNEY DISEASE THROUGH GENETIC MECHANISMS, DIAGNOSTICS, AND THERAPEUTIC INNOVATIONS.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(1), 17-21 (2025). https://doi.org/10.56121/2181-3612-2025-1-17-21
HarvardTashkenbayeva, Eleonora, Esankulov, Mukhammad, Ташкенбаева, Элеонора, Эсанкулов, Мухаммад, Tashkenbayeva, Eleonora, and Esankulov, Mukhammad (2025) ‘DECODING THE UMOD GENE: IMPLICATIONS FOR CHRONIC KIDNEY DISEASE THROUGH GENETIC MECHANISMS, DIAGNOSTICS, AND THERAPEUTIC INNOVATIONS’, Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(1), 17-21. https://doi.org/10.56121/2181-3612-2025-1-17-21
BibTeX
@article{tashkenbayevaeleonora2025,
  title = {DECODING THE UMOD GENE: IMPLICATIONS FOR CHRONIC KIDNEY DISEASE THROUGH GENETIC MECHANISMS, DIAGNOSTICS, AND THERAPEUTIC INNOVATIONS},
  author = {Tashkenbayeva, Eleonora and Esankulov, Mukhammad and Ташкенбаева, Элеонора and Эсанкулов, Мухаммад and Tashkenbayeva, Eleonora and Esankulov, Mukhammad},
  journal = {Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi},
  year = {2025},
  volume = {4},
  number = {1},
  pages = {17-21},
  doi = {10.56121/2181-3612-2025-1-17-21},
  url = {https://doi.org/10.56121/2181-3612-2025-1-17-21}
}

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